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CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation

CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation

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GAIDE, Olivier, Benoît FAVIER, Daniel F. LEGLER, David BONNET, Brian BRISSONI, Salvatore VALITUTTI, Claude BRON, Jürg TSCHOPP, Margot THOME, 2002. CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation. In: Nature Immunology. 3(9), pp. 836-843. ISSN 1529-2908. eISSN 1529-2916. Available under: doi: 10.1038/ni830

@article{Gaide2002CARMA-36629, title={CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation}, year={2002}, doi={10.1038/ni830}, number={9}, volume={3}, issn={1529-2908}, journal={Nature Immunology}, pages={836--843}, author={Gaide, Olivier and Favier, Benoît and Legler, Daniel F. and Bonnet, David and Brissoni, Brian and Valitutti, Salvatore and Bron, Claude and Tschopp, Jürg and Thome, Margot} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/36629"> <dc:contributor>Legler, Daniel F.</dc:contributor> <dc:contributor>Tschopp, Jürg</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-01-12T10:06:43Z</dcterms:available> <dc:contributor>Gaide, Olivier</dc:contributor> <dc:creator>Bron, Claude</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Thome, Margot</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/36629"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:abstract xml:lang="eng">CARMA1 is a lymphocyte-specific member of the membrane-associated guanylate kinase (MAGUK) family of scaffolding proteins, which coordinate signaling pathways emanating from the plasma membrane. CARMA1 interacts with Bcl10 via its caspase-recruitment domain (CARD). Here we investigated the role of CARMA1 in T cell activation and found that T cell receptor (TCR) stimulation induced a physical association of CARMA1 with the TCR and Bcl10. We found that CARMA1 was constitutively associated with lipid rafts, whereas cytoplasmic Bcl10 translocated into lipid rafts upon TCR engagement. A CARMA1 mutant, defective for Bcl10 binding, had a dominant-negative (DN) effect on TCR-induced NF-kappa B activation and IL-2 production and on the c-Jun NH(2)-terminal kinase (Jnk) pathway when the TCR was coengaged with CD28. Together, our data show that CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation and CD28 costimulation-dependent Jnk activation.</dcterms:abstract> <dc:creator>Bonnet, David</dc:creator> <dcterms:issued>2002</dcterms:issued> <dc:creator>Brissoni, Brian</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Tschopp, Jürg</dc:creator> <dc:contributor>Brissoni, Brian</dc:contributor> <dc:contributor>Bron, Claude</dc:contributor> <dc:creator>Favier, Benoît</dc:creator> <dc:creator>Valitutti, Salvatore</dc:creator> <dc:creator>Gaide, Olivier</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-01-12T10:06:43Z</dc:date> <dc:contributor>Favier, Benoît</dc:contributor> <dc:contributor>Valitutti, Salvatore</dc:contributor> <dcterms:title>CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation</dcterms:title> <dc:contributor>Bonnet, David</dc:contributor> <dc:creator>Legler, Daniel F.</dc:creator> <dc:language>eng</dc:language> <dc:creator>Thome, Margot</dc:creator> </rdf:Description> </rdf:RDF>

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