The αvβ 3 integrin as a tumor homing ligand for lymphocytes


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LEGLER, Daniel F., Caroline JOHNSON-LÉGER, Guido WIEDLE, Claude BRON, Beat A. IMHOF, 2004. The αvβ 3 integrin as a tumor homing ligand for lymphocytes. In: European Journal of Immunology. 34(6), pp. 1608-1616. ISSN 0014-2980. eISSN 1521-4141. Available under: doi: 10.1002/eji.200424938

@article{Legler2004integ-36624, title={The αvβ 3 integrin as a tumor homing ligand for lymphocytes}, year={2004}, doi={10.1002/eji.200424938}, number={6}, volume={34}, issn={0014-2980}, journal={European Journal of Immunology}, pages={1608--1616}, author={Legler, Daniel F. and Johnson-Léger, Caroline and Wiedle, Guido and Bron, Claude and Imhof, Beat A.} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dcterms:title>The αvβ 3 integrin as a tumor homing ligand for lymphocytes</dcterms:title> <dc:contributor>Johnson-Léger, Caroline</dc:contributor> <dcterms:rights rdf:resource=""/> <dc:contributor>Wiedle, Guido</dc:contributor> <dcterms:hasPart rdf:resource=""/> <dcterms:available rdf:datatype="">2017-01-12T09:21:25Z</dcterms:available> <dc:rights>terms-of-use</dc:rights> <dc:contributor>Imhof, Beat A.</dc:contributor> <dcterms:abstract xml:lang="eng">Despite the presence of tumor-specific effector cells in the circulation of cancer patients, the immune response of the majority of these patients is not sufficient to prevent the growth and spread of their tumors. That tumor cells can be killed in vitro by tumor-reactive cytotoxic T cells is testimony to the fact that the tumors are not inherently resistant to T cell killing, but rather that there is a failure in immune recognition and effector cell activation. Many reasons for this failure of the body's defense system have been suggested, including the inability of tumor-reactive lymphocytes to migrate to tumor tissue. Here we designed a strategy to improve homing of primary lymphocytes into vascularized tumors. As a homing molecule we selected the integrin alpha v beta 3 since it is expressed by angiogenic vascular endothelium in tumors. To promote lymphocyte adhesion to alpha v beta 3 we "painted" primary lymphocytes with a recombinant, glycosylphosphatidylinositol-linked high-affinity ligand for alpha v beta 3. These painted lymphocytes specifically bound to alpha v beta 3 in vitro and homed to vascularized, solid tumors in vivo. This novel strategy may provide a significant advance in anti-tumor treatment such as adoptive immune therapy.</dcterms:abstract> <dc:language>eng</dc:language> <dc:creator>Legler, Daniel F.</dc:creator> <dc:contributor>Legler, Daniel F.</dc:contributor> <dcterms:isPartOf rdf:resource=""/> <dc:creator>Wiedle, Guido</dc:creator> <dc:creator>Imhof, Beat A.</dc:creator> <dc:creator>Bron, Claude</dc:creator> <dcterms:issued>2004</dcterms:issued> <dc:date rdf:datatype="">2017-01-12T09:21:25Z</dc:date> <dspace:hasBitstream rdf:resource=""/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Bron, Claude</dc:contributor> <dspace:isPartOfCollection rdf:resource=""/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Johnson-Léger, Caroline</dc:creator> <bibo:uri rdf:resource=""/> </rdf:Description> </rdf:RDF>

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