Angiogenesis and lymphangiogenesis are downregulated in primary breast cancer


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BONEBERG, Eva-Maria, Daniel F. LEGLER, Melanie M. HOEFER, Christian ÖHLSCHLEGEL, Helmuth STEININGER, Laszlo FÜZESI, Gertrude M. BEER, Véronique DUPONT-LAMPERT, Florian OTTO, Gregor FÜRSTENBERGER, 2009. Angiogenesis and lymphangiogenesis are downregulated in primary breast cancer. In: British Journal of Cancer. 101(4), pp. 605-614. ISSN 0007-0920. eISSN 1532-1827

@article{Boneberg2009Angio-36608, title={Angiogenesis and lymphangiogenesis are downregulated in primary breast cancer}, year={2009}, doi={10.1038/sj.bjc.6605219}, number={4}, volume={101}, issn={0007-0920}, journal={British Journal of Cancer}, pages={605--614}, author={Boneberg, Eva-Maria and Legler, Daniel F. and Hoefer, Melanie M. and Öhlschlegel, Christian and Steininger, Helmuth and Füzesi, Laszlo and Beer, Gertrude M. and Dupont-Lampert, Véronique and Otto, Florian and Fürstenberger, Gregor} }

Füzesi, Laszlo 2017-01-12T08:30:25Z Boneberg, Eva-Maria Beer, Gertrude M. Steininger, Helmuth Öhlschlegel, Christian Dupont-Lampert, Véronique 2009 Hoefer, Melanie M. Legler, Daniel F. Hoefer, Melanie M. Boneberg, Eva-Maria Otto, Florian Füzesi, Laszlo Fürstenberger, Gregor Dupont-Lampert, Véronique Otto, Florian 2017-01-12T08:30:25Z Legler, Daniel F. Background: Angiogenesis and lymphangiogenesis are considered to play key roles in tumour growth, progression and metastasis. However, targeting tumour angiogenesis in clinical trials showed only modest efficacy. We therefore scrutinised the concept of tumour angiogenesis and lymphangiogenesis by analysing the expression of crucial markers involved in these processes in primary breast cancer.<br /><br />Methods: We analysed the expression of angiogenic, lymphangiogenic or antiangiogenic factors, their respective receptors and specific markers for endothelial and lymphendothelial cells by quantitative real-time RT-PCR in primary breast cancer and compared the expression profiles to non-cancerous, tumour-adjacent tissues and breast tissues from healthy women.<br /><br />Results: We found decreased mRNA amounts of major angiogenic and lymphangiogenic factors in tumour compared to healthy tissues, whereas antiangiogenic factors were upregulated. Concomitantly, angiogenic and lymphangiogenic receptors were downregulated in breast tumours. This antiangiogenic, antilymphangiogenic microenvironment was even more pronounced in aggressive tumours and accompanied by reduced amounts of endothelial and lymphatic endothelial cell markers.<br /><br />Conclusion: Primary breast tumours are not a site of highly active angiogenesis and lymphangiogenesis. Selection for tumour cells that survive with minimal vascular supply may account for this observation in clinical apparent tumours. Angiogenesis and lymphangiogenesis are downregulated in primary breast cancer Beer, Gertrude M. Fürstenberger, Gregor Steininger, Helmuth eng Öhlschlegel, Christian

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