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Association of the Epstein-Barr virus latent membrane protein 1 with lipid rafts is mediated through its N-terminal region

Association of the Epstein-Barr virus latent membrane protein 1 with lipid rafts is mediated through its N-terminal region

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ROTHENBERGER, Sylvia, Marga ROUSSEAUX, Hans KNECHT, Florent C. BENDER, Daniel F. LEGLER, Claude BRON, 2002. Association of the Epstein-Barr virus latent membrane protein 1 with lipid rafts is mediated through its N-terminal region. In: Cellular and Molecular Life Sciences : CMLS. 59(1), pp. 171-180. ISSN 1420-682X. eISSN 1420-9071. Available under: doi: 10.1007/s00018-002-8413-y

@article{Rothenberger2002-01-01Assoc-36551, title={Association of the Epstein-Barr virus latent membrane protein 1 with lipid rafts is mediated through its N-terminal region}, year={2002}, doi={10.1007/s00018-002-8413-y}, number={1}, volume={59}, issn={1420-682X}, journal={Cellular and Molecular Life Sciences : CMLS}, pages={171--180}, author={Rothenberger, Sylvia and Rousseaux, Marga and Knecht, Hans and Bender, Florent C. and Legler, Daniel F. and Bron, Claude} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/36551"> <dc:creator>Bender, Florent C.</dc:creator> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/36551/1/Rothenberger_0-366226.pdf"/> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/36551/1/Rothenberger_0-366226.pdf"/> <dc:contributor>Rothenberger, Sylvia</dc:contributor> <dc:contributor>Knecht, Hans</dc:contributor> <dc:creator>Knecht, Hans</dc:creator> <dc:creator>Legler, Daniel F.</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-01-10T14:41:11Z</dcterms:available> <dc:creator>Rothenberger, Sylvia</dc:creator> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/36551"/> <dc:language>eng</dc:language> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:issued>2002-01-01</dcterms:issued> <dc:creator>Rousseaux, Marga</dc:creator> <dcterms:title>Association of the Epstein-Barr virus latent membrane protein 1 with lipid rafts is mediated through its N-terminal region</dcterms:title> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-01-10T14:41:11Z</dc:date> <dc:contributor>Bron, Claude</dc:contributor> <dc:contributor>Legler, Daniel F.</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Bender, Florent C.</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.de/urn:nbn:de:bsz:352-20150914100631302-4485392-8"/> <dc:contributor>Rousseaux, Marga</dc:contributor> <dc:creator>Bron, Claude</dc:creator> <dcterms:abstract xml:lang="eng">The latent membrane protein 1 (LMP1) encoded by the Epstein-Barr virus acts like a constitutively activated receptor of the tumor necrosis factor receptor (TNFR) family and is enriched in lipid rafts. We showed that LMP1 is targeted to lipid rafts in transfected HEK 293 cells, and that the endogenous TNFR-associated factor 3 binds LMP1 and is recruited to lipid rafts upon LMP1 expression. An LMP1 mutant lacking the C-terminal 55 amino acids (CΔ55) behaves like the wild-type (WT) LMP1 with respect to membrane localization. In contrast, a mutant with a deletion of the 25 N-terminal residues (NΔ25) does not concentrate in lipid rafts but still binds TRAF3, demonstrating that cell localization of LMP1 was not crucial for TRAF3 localization. Moreover, NΔ25 inhibited WT LMP1-mediated induction of the transcription factors NF-κB and AP-1. Morphological data indicate that NΔ25 hampers WT LMP1 plasma membrane localization, thus blocking LMP1 function.</dcterms:abstract> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 10.01.2017 (Informationen über die Zugriffsstatistik)

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