KOPS - Das Institutionelle Repositorium der Universität Konstanz

Increased Mobility of Major Histocompatibility Complex I-Peptide Complexes Decreases the Sensitivity of Antigen Recognition

Increased Mobility of Major Histocompatibility Complex I-Peptide Complexes Decreases the Sensitivity of Antigen Recognition

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:431312795a8c02791e8af0a3433a4186

SEGURA, Jean-Manuel, Philippe GUILLAUME, Silke MARK, Danijel DOJCINOVIC, Alexandre JOHANNSEN, Giovanna BOSSHARD, Georgi ANGELOV, Daniel F. LEGLER, Horst VOGEL, Immanuel F. LUESCHER, 2008. Increased Mobility of Major Histocompatibility Complex I-Peptide Complexes Decreases the Sensitivity of Antigen Recognition. In: The Journal of Biological Chemistry : JBC. 283(35), pp. 24254-24263. ISSN 0021-9258. eISSN 1083-351X. Available under: doi: 10.1074/jbc.M803549200

@article{Segura2008-06-04Incre-36058, title={Increased Mobility of Major Histocompatibility Complex I-Peptide Complexes Decreases the Sensitivity of Antigen Recognition}, year={2008}, doi={10.1074/jbc.M803549200}, number={35}, volume={283}, issn={0021-9258}, journal={The Journal of Biological Chemistry : JBC}, pages={24254--24263}, author={Segura, Jean-Manuel and Guillaume, Philippe and Mark, Silke and Dojcinovic, Danijel and Johannsen, Alexandre and Bosshard, Giovanna and Angelov, Georgi and Legler, Daniel F. and Vogel, Horst and Luescher, Immanuel F.} }

2016-11-23T14:56:47Z eng Dojcinovic, Danijel 2008-06-04 Angelov, Georgi Mark, Silke CD8<sup>+</sup> cytotoxic T lymphocytes (CTL) can recognize and kill target cells expressing only a few cognate major histocompatibility complex (MHC) I-peptide complexes. This high sensitivity requires efficient scanning of a vast number of highly diverse MHC I-peptide complexes by the T cell receptor in the contact site of transient conjugates formed mainly by nonspecific interactions of ICAM-1 and LFA-1. Tracking of single H-2K<sup>d</sup> molecules loaded with fluorescent peptides on target cells and nascent conjugates with CTL showed dynamic transitions between states of free diffusion and immobility. The immobilizations were explained by association of MHC I-peptide complexes with ICAM-1 and strongly increased their local concentration in cell adhesion sites and hence their scanning by T cell receptor. In nascent immunological synapses cognate complexes became immobile, whereas noncognate ones diffused out again. Interfering with this mobility modulation-based concentration and sorting of MHC I-peptide complexes strongly impaired the sensitivity of antigen recognition by CTL, demonstrating that it constitutes a new basic aspect of antigen presentation by MHC I molecules. Segura, Jean-Manuel Legler, Daniel F. Dojcinovic, Danijel Bosshard, Giovanna Guillaume, Philippe Vogel, Horst Johannsen, Alexandre Luescher, Immanuel F. Increased Mobility of Major Histocompatibility Complex I-Peptide Complexes Decreases the Sensitivity of Antigen Recognition Segura, Jean-Manuel Mark, Silke Luescher, Immanuel F. Angelov, Georgi Vogel, Horst 2016-11-23T14:56:47Z Bosshard, Giovanna Guillaume, Philippe Johannsen, Alexandre Legler, Daniel F.

Dateiabrufe seit 23.11.2016 (Informationen über die Zugriffsstatistik)

Segura_0-366132.pdf 10

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto