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Biting into the Genome to Phenome Map : Developmental Genetic Modularity of Cichlid Fish Dentitions

Biting into the Genome to Phenome Map : Developmental Genetic Modularity of Cichlid Fish Dentitions

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HULSEY, C. Darrin, Gareth J. FRASER, Axel MEYER, 2016. Biting into the Genome to Phenome Map : Developmental Genetic Modularity of Cichlid Fish Dentitions. In: Integrative and Comparative Biology. 56(3), pp. 373-388. ISSN 1540-7063. eISSN 1557-7023

@article{Hulsey2016-06-02Bitin-35116, title={Biting into the Genome to Phenome Map : Developmental Genetic Modularity of Cichlid Fish Dentitions}, year={2016}, doi={10.1093/icb/icw059}, number={3}, volume={56}, issn={1540-7063}, journal={Integrative and Comparative Biology}, pages={373--388}, author={Hulsey, C. Darrin and Fraser, Gareth J. and Meyer, Axel} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/35116"> <dcterms:rights rdf:resource="http://nbn-resolving.de/urn:nbn:de:bsz:352-20150914100631302-4485392-8"/> <dc:language>eng</dc:language> <dc:creator>Meyer, Axel</dc:creator> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/35116"/> <dc:contributor>Meyer, Axel</dc:contributor> <dc:creator>Fraser, Gareth J.</dc:creator> <dcterms:issued>2016-06-02</dcterms:issued> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-09-05T11:43:42Z</dcterms:available> <dc:contributor>Hulsey, C. Darrin</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-09-05T11:43:42Z</dc:date> <dcterms:abstract xml:lang="eng">Within vertebrates, teleost fishes provide a rich evolutionary context for studying the mechanisms of dental divergence because of the numerous axes along which their teeth have diverged phenotypically and presumably developmentally. Using both a review of teleost in situ hybridization and de novo transcriptome sequencing in a cichlid fish, we examined whether 341 gene homologs thought to play a role in developing mice teeth are expressed in the tooth-bearing jaws of teleosts. The similarities and putative differences in gene expression documented between the two most commonly used models, zebrafish and cichlids, highlight what can be learned from using a greater diversity of teleost model systems in studies of tooth development. Both types of gene expression analysis also provide substantial evidence for conservation of tooth gene expression from teleosts to mammals as well as between initial and replacement teeth. Additionally, we found that the cichlid oral and pharyngeal jaws share expression for a large percentage of genes that influence tooth development. Our transcriptome analyses also suggest sub-functionalization between gene paralogs expressed in teeth and paralogs expressed in other structures is likely a common pattern across teleost diversity. Teleost dentitions will continue to provide a potent system in which to examine the importance of both gene duplication as well as the conservation of gene expression for phenotypic diversification.</dcterms:abstract> <dc:creator>Hulsey, C. Darrin</dc:creator> <dc:contributor>Fraser, Gareth J.</dc:contributor> <dcterms:title>Biting into the Genome to Phenome Map : Developmental Genetic Modularity of Cichlid Fish Dentitions</dcterms:title> </rdf:Description> </rdf:RDF>

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