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Aversive Learning and Appetitive Motivation Toggle Feed-Forward Inhibition in the Drosophila Mushroom Body

Aversive Learning and Appetitive Motivation Toggle Feed-Forward Inhibition in the Drosophila Mushroom Body

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Prüfsumme: MD5:1270dbff9f148ebb1d22d6053dd5a038

PERISSE, Emmanuel, David OWALD, Oliver BARNSTEDT, Clifford B. TALBOT, Wolf HUETTEROTH, Scott WADDELL, 2016. Aversive Learning and Appetitive Motivation Toggle Feed-Forward Inhibition in the Drosophila Mushroom Body. In: Neuron. 90(5), pp. 1086-1099. ISSN 0896-6273. eISSN 1097-4199. Available under: doi: 10.1016/j.neuron.2016.04.034

@article{Perisse2016-06-01Avers-34791, title={Aversive Learning and Appetitive Motivation Toggle Feed-Forward Inhibition in the Drosophila Mushroom Body}, year={2016}, doi={10.1016/j.neuron.2016.04.034}, number={5}, volume={90}, issn={0896-6273}, journal={Neuron}, pages={1086--1099}, author={Perisse, Emmanuel and Owald, David and Barnstedt, Oliver and Talbot, Clifford B. and Huetteroth, Wolf and Waddell, Scott} }

eng In Drosophila, negatively reinforcing dopaminergic neurons also provide the inhibitory control of satiety over appetitive memory expression. Here we show that aversive learning causes a persistent depression of the conditioned odor drive to two downstream feed-forward inhibitory GABAergic interneurons of the mushroom body, called MVP2, or mushroom body output neuron (MBON)-γ1pedc>α/β. However, MVP2 neuron output is only essential for expression of short-term aversive memory. Stimulating MVP2 neurons preferentially inhibits the odor-evoked activity of avoidance-directing MBONs and odor-driven avoidance behavior, whereas their inhibition enhances odor avoidance. In contrast, odor-evoked activity of MVP2 neurons is elevated in hungry flies, and their feed-forward inhibition is required for expression of appetitive memory at all times. Moreover, imposing MVP2 activity promotes inappropriate appetitive memory expression in food-satiated flies. Aversive learning and appetitive motivation therefore toggle alternate modes of a common feed-forward inhibitory MVP2 pathway to promote conditioned odor avoidance or approach. 2016-07-15T09:23:08Z Owald, David Waddell, Scott Talbot, Clifford B. 2016-07-15T09:23:08Z Aversive Learning and Appetitive Motivation Toggle Feed-Forward Inhibition in the Drosophila Mushroom Body Owald, David Waddell, Scott Perisse, Emmanuel 2016-06-01 Talbot, Clifford B. Barnstedt, Oliver Barnstedt, Oliver Huetteroth, Wolf Huetteroth, Wolf Perisse, Emmanuel

Dateiabrufe seit 15.07.2016 (Informationen über die Zugriffsstatistik)

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