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4'-Acylated thymidine 5'-triphosphates : a tool to increase selectivity towards HIV-1 reverse transcriptase

4'-Acylated thymidine 5'-triphosphates : a tool to increase selectivity towards HIV-1 reverse transcriptase

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MARX, Andreas, Bernd GIESE, Mario AMACKER, Manuel STUCKI, Ulrich HÜBSCHER, Thomas A. BICKLE, 1998. 4'-Acylated thymidine 5'-triphosphates : a tool to increase selectivity towards HIV-1 reverse transcriptase. In: Nucleic Acids Research. 26(17), pp. 4063-4067. ISSN 0305-1048. eISSN 1362-4962

@article{Marx1998-09-014'-Ac-33965, title={4'-Acylated thymidine 5'-triphosphates : a tool to increase selectivity towards HIV-1 reverse transcriptase}, year={1998}, doi={10.1093/nar/26.17.4063}, number={17}, volume={26}, issn={0305-1048}, journal={Nucleic Acids Research}, pages={4063--4067}, author={Marx, Andreas and Giese, Bernd and Amacker, Mario and Stucki, Manuel and Hübscher, Ulrich and Bickle, Thomas A.} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/33965"> <dc:creator>Marx, Andreas</dc:creator> <dc:creator>Giese, Bernd</dc:creator> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/33965"/> <dc:contributor>Stucki, Manuel</dc:contributor> <dcterms:abstract xml:lang="eng">4′-Acylated thymidines represent a new class of DNA chain terminators, since they have been shown to act as post-incorporation chain-terminating nucleotides despite the presence of a free 3′-hydroxyl group. Here, we describe the action of the 4′-acetyl- (MeTTP) and 4′-propanoylthymidine 5′-triphosphate (EtTTP) on HIV-1 reverse transcriptase in RNA- and DNA-dependent DNA synthesis and on DNA synthesis catalyzed by the cellular DNA polymerases α, β, δ and ε. MeTTP exhibits a high selectivity towards HIV-1 reverse transcriptase. By the use of the bulkier propanoyl group as the 4′-substituent of the nucleoside 5′-triphosphate, selectivity towards HIV-1 reverse transcriptase could be increased without affecting substrate efficiency. Thus, 4′-modifications may serve as a tool to increase selectivity towards HIV-1 reverse transcriptase.</dcterms:abstract> <dc:contributor>Giese, Bernd</dc:contributor> <dc:creator>Bickle, Thomas A.</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-05-18T08:00:02Z</dcterms:available> <dc:language>eng</dc:language> <dc:contributor>Hübscher, Ulrich</dc:contributor> <dcterms:issued>1998-09-01</dcterms:issued> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-05-18T08:00:02Z</dc:date> <dc:contributor>Marx, Andreas</dc:contributor> <dc:creator>Stucki, Manuel</dc:creator> <dc:creator>Amacker, Mario</dc:creator> <dc:contributor>Bickle, Thomas A.</dc:contributor> <dc:creator>Hübscher, Ulrich</dc:creator> <dc:contributor>Amacker, Mario</dc:contributor> <dcterms:title>4'-Acylated thymidine 5'-triphosphates : a tool to increase selectivity towards HIV-1 reverse transcriptase</dcterms:title> </rdf:Description> </rdf:RDF>

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