Molecular Architecture of the 40S⋅eIF1⋅eIF3 Translation Initiation Complex

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:91b8e6c0ab49b43a96f11513195a88b4

ERZBERGER, Jan P., Florian STENGEL, Riccardo PELLARIN, Suyang ZHANG, Tanja SCHAEFER, Christopher H.S. AYLETT, Peter CIMERMANČIČ, Daniel BOEHRINGER, Andrej SALI, Ruedi AEBERSOLD, Nenad BAN, 2014. Molecular Architecture of the 40S⋅eIF1⋅eIF3 Translation Initiation Complex. In: Cell. 158(5), pp. 1123-1135. ISSN 0092-8674. eISSN 1097-4172. Available under: doi: 10.1016/j.cell.2014.07.044

@article{Erzberger2014-08Molec-33544, title={Molecular Architecture of the 40S⋅eIF1⋅eIF3 Translation Initiation Complex}, year={2014}, doi={10.1016/j.cell.2014.07.044}, number={5}, volume={158}, issn={0092-8674}, journal={Cell}, pages={1123--1135}, author={Erzberger, Jan P. and Stengel, Florian and Pellarin, Riccardo and Zhang, Suyang and Schaefer, Tanja and Aylett, Christopher H.S. and Cimermančič, Peter and Boehringer, Daniel and Sali, Andrej and Aebersold, Ruedi and Ban, Nenad} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/33544"> <dc:contributor>Stengel, Florian</dc:contributor> <dc:contributor>Sali, Andrej</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.de/urn:nbn:de:bsz:352-20150914100631302-4485392-8"/> <dc:creator>Cimermančič, Peter</dc:creator> <dc:creator>Pellarin, Riccardo</dc:creator> <dc:contributor>Boehringer, Daniel</dc:contributor> <dc:contributor>Cimermančič, Peter</dc:contributor> <dc:creator>Zhang, Suyang</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-04-05T12:56:11Z</dc:date> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/33544/1/Erzberger_0-314818.pdf"/> <dcterms:abstract xml:lang="eng">Eukaryotic translation initiation requires the recruitment of the large, multiprotein eIF3 complex to the 40S ribosomal subunit. We present X-ray structures of all major components of the minimal, six-subunit Saccharomyces cerevisiae eIF3 core. These structures, together with electron microscopy reconstructions, cross-linking coupled to mass spectrometry, and integrative structure modeling, allowed us to position and orient all eIF3 components on the 40S⋅eIF1 complex, revealing an extended, modular arrangement of eIF3 subunits. Yeast eIF3 engages 40S in a clamp-like manner, fully encircling 40S to position key initiation factors on opposite ends of the mRNA channel, providing a platform for the recruitment, assembly, and regulation of the translation initiation machinery. The structures of eIF3 components reported here also have implications for understanding the architecture of the mammalian 43S preinitiation complex and the complex of eIF3, 40S, and the hepatitis C internal ribosomal entry site RNA.</dcterms:abstract> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:title>Molecular Architecture of the 40S⋅eIF1⋅eIF3 Translation Initiation Complex</dcterms:title> <dc:creator>Aebersold, Ruedi</dc:creator> <dc:contributor>Aylett, Christopher H.S.</dc:contributor> <dc:contributor>Erzberger, Jan P.</dc:contributor> <dc:creator>Erzberger, Jan P.</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-04-05T12:56:11Z</dcterms:available> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:issued>2014-08</dcterms:issued> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/33544"/> <dc:creator>Stengel, Florian</dc:creator> <dc:contributor>Zhang, Suyang</dc:contributor> <dc:creator>Sali, Andrej</dc:creator> <dc:contributor>Aebersold, Ruedi</dc:contributor> <dc:language>eng</dc:language> <dc:creator>Schaefer, Tanja</dc:creator> <dc:creator>Boehringer, Daniel</dc:creator> <dc:creator>Ban, Nenad</dc:creator> <dc:contributor>Schaefer, Tanja</dc:contributor> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/33544/1/Erzberger_0-314818.pdf"/> <dc:contributor>Ban, Nenad</dc:contributor> <dc:contributor>Pellarin, Riccardo</dc:contributor> <dc:creator>Aylett, Christopher H.S.</dc:creator> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 05.04.2016 (Informationen über die Zugriffsstatistik)

Erzberger_0-314818.pdf 36

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto