Targeted training modifies oscillatory brain activity in schizophrenia patients


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POPOV, Tzvetan G., Almut CAROLUS, David SCHUBRING, Petia POPOVA, Gregory A. MILLER, Brigitte S. ROCKSTROH, 2015. Targeted training modifies oscillatory brain activity in schizophrenia patients. In: NeuroImage : Clinical. 7, pp. 807-814. ISSN 2213-1582. eISSN 2213-1582. Available under: doi: 10.1016/j.nicl.2015.03.010

@article{Popov2015Targe-33281, title={Targeted training modifies oscillatory brain activity in schizophrenia patients}, year={2015}, doi={10.1016/j.nicl.2015.03.010}, volume={7}, issn={2213-1582}, journal={NeuroImage : Clinical}, pages={807--814}, author={Popov, Tzvetan G. and Carolus, Almut and Schubring, David and Popova, Petia and Miller, Gregory A. and Rockstroh, Brigitte S.} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dc:contributor>Miller, Gregory A.</dc:contributor> <dcterms:title>Targeted training modifies oscillatory brain activity in schizophrenia patients</dcterms:title> <dc:rights>terms-of-use</dc:rights> <dcterms:issued>2015</dcterms:issued> <dc:contributor>Popova, Petia</dc:contributor> <dc:language>eng</dc:language> <bibo:uri rdf:resource=""/> <dcterms:available rdf:datatype="">2016-03-09T10:24:55Z</dcterms:available> <dcterms:rights rdf:resource=""/> <dc:contributor>Popov, Tzvetan G.</dc:contributor> <dc:date rdf:datatype="">2016-03-09T10:24:55Z</dc:date> <dc:contributor>Schubring, David</dc:contributor> <dc:creator>Schubring, David</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Miller, Gregory A.</dc:creator> <dcterms:abstract xml:lang="eng">Effects of both domain-specific and broader cognitive remediation protocols have been reported for neural activity and overt performance in schizophrenia (SZ). Progress is limited by insufficient knowledge of relevant neural mechanisms. Addressing neuronal signal resolution in the auditory system as a mechanism contributing to cognitive function and dysfunction in schizophrenia, the present study compared effects of two neuroplasticity-based training protocols targeting auditory-verbal or facial affect discrimination accuracy and a standard rehabilitation protocol on magnetoencephalographic (MEG) oscillatory brain activity in an auditory paired-click task. SZ were randomly assigned to either 20 daily 1-hour sessions over 4 weeks of auditory-verbal training (N = 19), similarly intense facial affect discrimination training (N = 19), or 4 weeks of treatment as usual (TAU, N = 19). Pre-training, the 57 SZ showed smaller click-induced posterior alpha power modulation than did 28 healthy comparison participants, replicating Popov et al. (2011b). Abnormally small alpha decrease 300-800 ms around S2 improved more after targeted auditory-verbal training than after facial affect training or TAU. The improvement in oscillatory brain dynamics with training correlated with improvement on a measure of verbal learning. Results replicate previously reported effects of neuroplasticity-based psychological training on oscillatory correlates of auditory stimulus differentiation, encoding, and updating and indicate specificity of cortical training effects.</dcterms:abstract> <dc:contributor>Rockstroh, Brigitte S.</dc:contributor> <dc:creator>Popova, Petia</dc:creator> <dspace:isPartOfCollection rdf:resource=""/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dspace:hasBitstream rdf:resource=""/> <dc:creator>Popov, Tzvetan G.</dc:creator> <dcterms:hasPart rdf:resource=""/> <dcterms:isPartOf rdf:resource=""/> <dc:contributor>Carolus, Almut</dc:contributor> <dc:creator>Carolus, Almut</dc:creator> <dc:creator>Rockstroh, Brigitte S.</dc:creator> </rdf:Description> </rdf:RDF>

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