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The Cortisol Paradox of Trauma-Related Disorders : Lower Phasic Responses but Higher Tonic Levels of Cortisol Are Associated with Sexual Abuse in Childhood

The Cortisol Paradox of Trauma-Related Disorders : Lower Phasic Responses but Higher Tonic Levels of Cortisol Are Associated with Sexual Abuse in Childhood

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Prüfsumme: MD5:9e5c820885fa77f388c882d834f5e397

SCHALINSKI, Inga, Thomas ELBERT, Susann STEUDTE-SCHMIEDGEN, Clemens KIRSCHBAUM, 2015. The Cortisol Paradox of Trauma-Related Disorders : Lower Phasic Responses but Higher Tonic Levels of Cortisol Are Associated with Sexual Abuse in Childhood. In: PloS one. 10(8), e0136921. eISSN 1932-6203. Available under: doi: 10.1371/journal.pone.0136921

@article{Schalinski2015Corti-33265, title={The Cortisol Paradox of Trauma-Related Disorders : Lower Phasic Responses but Higher Tonic Levels of Cortisol Are Associated with Sexual Abuse in Childhood}, year={2015}, doi={10.1371/journal.pone.0136921}, number={8}, volume={10}, journal={PloS one}, author={Schalinski, Inga and Elbert, Thomas and Steudte-Schmiedgen, Susann and Kirschbaum, Clemens}, note={Article Number: e0136921} }

Steudte-Schmiedgen, Susann 2016-03-08T12:08:18Z Steudte-Schmiedgen, Susann Kirschbaum, Clemens The Cortisol Paradox of Trauma-Related Disorders : Lower Phasic Responses but Higher Tonic Levels of Cortisol Are Associated with Sexual Abuse in Childhood Objectives<br />Inconsistent findings exist for the activity of the hypothalamic-pituitary-adrenal (HPA) axis in patients with stress related disorders. Recent studies point towards early life stress as a potential modulator.<br /><br />Methods<br />We investigated the impact of childhood sexual abuse on phasic (saliva cortisol reactivity) and tonic (hair cortisol) regulation. Furthermore, we assessed predictors on cortisol accumulation in hair. Women (N = 43) with stress-related disorders underwent a standardized assessment of idiographic adverse and traumatic experiences and psychopathology, while measuring salivary cortisol and, heart rate and blood pressure.<br /><br />Results<br />Comparing women with and without childhood sexual abuse revealed lower rates of responders and distinct levels of salivary cortisol to the interview in conjunction with a lower heart rate for the abused group. Childhood adversities, traumatic experiences, and depression contributed to higher hair cortisol levels.<br /><br />Conclusions<br />Our finding of lower response rate and distinct salivary cortisol pattern in individuals with childhood sexual abuse compared to individuals without early sexual abuse supports the role of environmental programming for the HPA axis. Both, childhood adversities and traumatic stress emerge as crucial factors for long-term cortisol secretion. Lower or suppressed phasic cortisol responses to trauma-related stimuli may therefore be associated with higher tonic values. Thus, early exposure to adversities may result in a biological distinct phenotype in adult patients with stress-related disorders. 2016-03-08T12:08:18Z eng Elbert, Thomas Schalinski, Inga Schalinski, Inga Elbert, Thomas 2015 Kirschbaum, Clemens

Dateiabrufe seit 08.03.2016 (Informationen über die Zugriffsstatistik)

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