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Pulsed EPR spectroscopy distance measurements of DNA internally labelled with Gd<sup>3+</sup>-DOTA

Pulsed EPR spectroscopy distance measurements of DNA internally labelled with Gd3+-DOTA

Type of Publication: Journal article
Publication status: Published
URI (citable link): http://nbn-resolving.de/urn:nbn:de:bsz:352-0-302666
Author: Wojciechowski, Filip; Groß, Andreas; Holder, Isabelle T.; Knörr, Laura; Drescher, Malte; Hartig, Jörg S.
Year of publication: 2015
Published in: Chemical communications ; 51 (2015), 72. - pp. 13850-13853. - ISSN 0009-241X. - eISSN 1364-548X
DOI (citable link): https://dx.doi.org/10.1039/c5cc04234h
Summary:
Gd3+ is increasingly used in EPR spectroscopy due to its increased intracellular stability and signal-to-noise ratios. Here we present the incorporation of Gd3+-DOTA into internal positions in DNA. Distance measurements via pulsed Electron Paramagnetic Resonance (EPR) spectroscopy in vitro and in cellula proved enhanced stability and efficiency compared to nitroxide labels.
Subject (DDC): 540 Chemistry
Link to License: Terms of use
Bibliography of Konstanz: Yes

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WOJCIECHOWSKI, Filip, Andreas GROSS, Isabelle T. HOLDER, Laura KNÖRR, Malte DRESCHER, Jörg S. HARTIG, 2015. Pulsed EPR spectroscopy distance measurements of DNA internally labelled with Gd3+-DOTA. In: Chemical communications. 51(72), pp. 13850-13853. ISSN 0009-241X. eISSN 1364-548X. Available under: doi: 10.1039/c5cc04234h

@article{Wojciechowski2015Pulse-33144, title={Pulsed EPR spectroscopy distance measurements of DNA internally labelled with Gd3+-DOTA}, year={2015}, doi={10.1039/c5cc04234h}, number={72}, volume={51}, issn={0009-241X}, journal={Chemical communications}, pages={13850--13853}, author={Wojciechowski, Filip and Groß, Andreas and Holder, Isabelle T. and Knörr, Laura and Drescher, Malte and Hartig, Jörg S.} }

Wojciechowski, Filip Drescher, Malte Knörr, Laura eng Gd<sup>3+</sup> is increasingly used in EPR spectroscopy due to its increased intracellular stability and signal-to-noise ratios. Here we present the incorporation of Gd<sup>3+</sup>-DOTA into internal positions in DNA. Distance measurements via pulsed Electron Paramagnetic Resonance (EPR) spectroscopy in vitro and in cellula proved enhanced stability and efficiency compared to nitroxide labels. 2015 Groß, Andreas 2016-02-29T13:33:55Z Groß, Andreas 2016-02-29T13:33:55Z Holder, Isabelle T. Drescher, Malte terms-of-use Knörr, Laura Holder, Isabelle T. Hartig, Jörg S. Hartig, Jörg S. Pulsed EPR spectroscopy distance measurements of DNA internally labelled with Gd<sup>3+</sup>-DOTA Wojciechowski, Filip

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