Cell death at the intestinal epithelial front line

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:39a80bb45620afe3d10d88fb2bd4c07d

DELGADO, Maria Eugenia, Thomas GRABINGER, Thomas BRUNNER, 2016. Cell death at the intestinal epithelial front line. In: The FEBS Journal. 283(14), pp. 2701-19. ISSN 0014-2956. eISSN 1432-1033. Available under: doi: 10.1111/febs.13575

@article{Delgado2016-07death-33060, title={Cell death at the intestinal epithelial front line}, year={2016}, doi={10.1111/febs.13575}, number={14}, volume={283}, issn={0014-2956}, journal={The FEBS Journal}, author={Delgado, Maria Eugenia and Grabinger, Thomas and Brunner, Thomas} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/33060"> <dc:creator>Grabinger, Thomas</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.de/urn:nbn:de:bsz:352-20150914100631302-4485392-8"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-02-19T13:33:49Z</dc:date> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/33060/1/Delgado_0-322673.pdf"/> <dc:contributor>Delgado, Maria Eugenia</dc:contributor> <dc:creator>Brunner, Thomas</dc:creator> <dc:contributor>Brunner, Thomas</dc:contributor> <dc:contributor>Grabinger, Thomas</dc:contributor> <dc:creator>Delgado, Maria Eugenia</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:issued>2016-07</dcterms:issued> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-02-19T13:33:49Z</dcterms:available> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/33060"/> <dcterms:title>Cell death at the intestinal epithelial front line</dcterms:title> <dc:language>eng</dc:language> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:abstract xml:lang="eng">The intestinal epithelium represents the largest epithelial surface in our body. This single cell-layer epithelium mediates important functions in the absorption of nutrients and in the maintenance of barrier function, preventing luminal microorganism from invading the body. Due to its constant regeneration the intestinal epithelium is not only a tissue with very high proliferation rates, but also with very prominent physiological and pathophysiological cell death induction. The normal physiological differentiation and maturation of intestinal epithelial cells (IECs) leads to their shedding and apoptotic cell death within few days, without disturbing the epithelial barrier integrity. In contrast excessive IEC cell death induced by irradiation, drugs and inflammation severely impairs the vital functions of this tissue. In this review we discuss cell death processes in the intestinal epithelium in health and disease, with special emphasis on TNF receptor family-triggered cell death.The intestinal epithelium represents the largest epithelial surface in our body. This single-cell-layer epithelium mediates important functions in the absorption of nutrients and in the maintenance of barrier function, preventing luminal microorganisms from invading the body. Due to its constant regeneration the intestinal epithelium is a tissue not only with very high proliferation rates but also with very prominent physiological and pathophysiological cell death induction. The normal physiological differentiation and maturation of intestinal epithelial cells leads to their shedding and apoptotic cell death within a few days, without disturbing the epithelial barrier integrity. In contrast excessive intestinal epithelial cell death induced by irradiation, drugs and inflammation severely impairs the vital functions of this tissue. In this review we discuss cell death processes in the intestinal epithelium in health and disease, with special emphasis on cell death triggered by the tumour necrosis factor receptor family.</dcterms:abstract> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/33060/1/Delgado_0-322673.pdf"/> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 19.02.2016 (Informationen über die Zugriffsstatistik)

Delgado_0-322673.pdf 20

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto