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Prostaglandin E(2) at new glance : Novel insights in functional diversity offer therapeutic chances

Prostaglandin E(2) at new glance : Novel insights in functional diversity offer therapeutic chances

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Prüfsumme: MD5:748e0bd4daa83c282669ee1e15f952c6

LEGLER, Daniel F., Markus BRUCKNER, Edith UETZ-ALLMEN, Petra KRAUSE, 2009. Prostaglandin E(2) at new glance : Novel insights in functional diversity offer therapeutic chances. In: The International Journal of Biochemistry & Cell Biology. 42(2), pp. 198-201. ISSN 1357-2725. eISSN 1878-5875. Available under: doi: 10.1016/j.biocel.2009.09.015

@article{Legler2009Prost-3303, title={Prostaglandin E(2) at new glance : Novel insights in functional diversity offer therapeutic chances}, year={2009}, doi={10.1016/j.biocel.2009.09.015}, number={2}, volume={42}, issn={1357-2725}, journal={The International Journal of Biochemistry & Cell Biology}, pages={198--201}, author={Legler, Daniel F. and Bruckner, Markus and Uetz-Allmen, Edith and Krause, Petra} }

Uetz-Allmen, Edith Bruckner, Markus deposit-license 2009 Publ. in: The International Journal of Biochemistry & Cell Biology 42 (2010), 2, pp. 198-201 Krause, Petra Prostaglandin E2 (PGE2) is the most abundant eicosanoid and a very potent lipid mediator. PGE2 is produced predominantly from arachidonic acid by its tightly regulated cyclooxygenases (COX) and prostaglandin E synthases (PGES). Secreted PGE2 acts in an autocrine or paracrine manner through its four cognate G protein coupled receptors EP1 to EP4. Under physiological conditions, PGE2 is key in many biological functions, such as regulation of immune responses, blood pressure, gastrointestinal integrity, and fertility. Deregulated PGE2 synthesis or degradation is associated with severe pathological conditions like chronic inflammation, Alzheimer's disease, or tumorigenesis. Therefore, pharmacological inhibition of COX enzymes and PGE2 receptor antagonism is of great therapeutic interest. 2011-03-23T10:19:58Z eng Prostaglandin E(2) at new glance : Novel insights in functional diversity offer therapeutic chances Krause, Petra Legler, Daniel F. 2011-03-23T10:19:58Z Legler, Daniel F. Uetz-Allmen, Edith Bruckner, Markus

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