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No fever and leucocytosis in response to a lipopolysaccharide challenge in an insectivorous bat

No fever and leucocytosis in response to a lipopolysaccharide challenge in an insectivorous bat

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STOCKMAIER, Sebastian, Dina K. N. DECHMANN, Rachel A. PAGE, M. Teague O'MARA, 2015. No fever and leucocytosis in response to a lipopolysaccharide challenge in an insectivorous bat. In: Biology Letters. 11(9), 20150576. ISSN 1744-9561. eISSN 1744-957X

@article{Stockmaier2015fever-32939, title={No fever and leucocytosis in response to a lipopolysaccharide challenge in an insectivorous bat}, year={2015}, doi={10.1098/rsbl.2015.0576}, number={9}, volume={11}, issn={1744-9561}, journal={Biology Letters}, author={Stockmaier, Sebastian and Dechmann, Dina K. N. and Page, Rachel A. and O'Mara, M. Teague}, note={Article Number: 20150576} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/32939"> <dcterms:issued>2015</dcterms:issued> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-02-11T08:56:18Z</dcterms:available> <dcterms:title>No fever and leucocytosis in response to a lipopolysaccharide challenge in an insectivorous bat</dcterms:title> <dc:creator>Dechmann, Dina K. N.</dc:creator> <dc:contributor>O'Mara, M. Teague</dc:contributor> <dc:contributor>Dechmann, Dina K. N.</dc:contributor> <dc:contributor>Stockmaier, Sebastian</dc:contributor> <dcterms:abstract xml:lang="eng">Bat immune systems may allow them to respond to zoonotic agents more efficiently than other mammals. As the first line of defence, the taxonomically conserved acute phase immune reaction of leucocytosis and fever is crucial for coping with infections, but it is unknown if this response is a key constituent to bat immunological success. We investigated the acute phase reaction to a standard lipopolysaccharide (LPS) challenge in Pallas's mastiff bats (Molossus molossus). Challenged bats lost mass, but in contrast to other mammals showed no leucocytosis or fever. There also was no influence on body temperature reduction during torpor. When compared to recent genome-wide assays for constituent immune genes, this lack of a conserved fever response to LPS contributes to a clearer understanding of the innate immune system in bat species and of the coevolution of bats with a wide diversity of pathogens.</dcterms:abstract> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/32939"/> <dc:creator>Page, Rachel A.</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-02-11T08:56:18Z</dc:date> <dc:creator>Stockmaier, Sebastian</dc:creator> <dc:creator>O'Mara, M. Teague</dc:creator> <dc:contributor>Page, Rachel A.</dc:contributor> <dc:language>eng</dc:language> </rdf:Description> </rdf:RDF>

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