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The Ubiquitin-like Modifier FAT10 Is Selectively Expressed in Medullary Thymic Epithelial Cells and Modifies T Cell Selection

The Ubiquitin-like Modifier FAT10 Is Selectively Expressed in Medullary Thymic Epithelial Cells and Modifies T Cell Selection

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BUERGER, Stefanie, Valerie L. HERRMANN, Sarah MUNDT, Nico TRAUTWEIN, Marcus GROETTRUP, Michael BASLER, 2015. The Ubiquitin-like Modifier FAT10 Is Selectively Expressed in Medullary Thymic Epithelial Cells and Modifies T Cell Selection. In: The Journal of Immunology. 195(9), pp. 4106-4116. ISSN 0022-1767. eISSN 1550-6606

@article{Buerger2015-11-01Ubiqu-32422, title={The Ubiquitin-like Modifier FAT10 Is Selectively Expressed in Medullary Thymic Epithelial Cells and Modifies T Cell Selection}, year={2015}, doi={10.4049/jimmunol.1500592}, number={9}, volume={195}, issn={0022-1767}, journal={The Journal of Immunology}, pages={4106--4116}, author={Buerger, Stefanie and Herrmann, Valerie L. and Mundt, Sarah and Trautwein, Nico and Groettrup, Marcus and Basler, Michael} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/32422"> <dc:contributor>Basler, Michael</dc:contributor> <dc:creator>Herrmann, Valerie L.</dc:creator> <dcterms:issued>2015-11-01</dcterms:issued> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-12-15T14:26:36Z</dcterms:available> <dc:creator>Basler, Michael</dc:creator> <dc:contributor>Groettrup, Marcus</dc:contributor> <dc:creator>Groettrup, Marcus</dc:creator> <dcterms:title>The Ubiquitin-like Modifier FAT10 Is Selectively Expressed in Medullary Thymic Epithelial Cells and Modifies T Cell Selection</dcterms:title> <dc:language>eng</dc:language> <dc:contributor>Mundt, Sarah</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-12-15T14:26:36Z</dc:date> <dc:contributor>Trautwein, Nico</dc:contributor> <dc:contributor>Herrmann, Valerie L.</dc:contributor> <dc:creator>Mundt, Sarah</dc:creator> <dc:contributor>Buerger, Stefanie</dc:contributor> <dc:creator>Trautwein, Nico</dc:creator> <dc:creator>Buerger, Stefanie</dc:creator> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/32422"/> <dcterms:abstract xml:lang="eng">HLA-F adjacent transcript 10 (FAT10) is a cytokine-inducible ubiquitin-like modifier that is highly expressed in the thymus and directly targets FAT10-conjugated proteins for degradation by the proteasome. High expression of FAT10 in the mouse thymus could be assigned to strongly autoimmune regulator-expressing, mature medullary thymic epithelial cells, which play a pivotal role in negative selection of T cells. Also in the human thymus, FAT10 is localized in the medulla but not the cortex. TCR Vβ-segment screening revealed a changed T cell repertoire in FAT10-deficient mice. Analysis of five MHC class I- and II-restricted TCR-transgenic mice demonstrated an altered thymic negative selection in FAT10-deficient mice. Furthermore, the repertoire of peptides eluted from MHC class I molecules was influenced by FAT10 expression. Hence, we identified FAT10 as a novel modifier of thymic Ag presentation and epitope-dependent elimination of self-reactive T cells, which may explain why the fat10 gene could recently be linked to enhanced susceptibility to virus-triggered autoimmune diabetes.</dcterms:abstract> </rdf:Description> </rdf:RDF>

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