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Accelerated ageing and effects of psychotherapy on DNA strand break accumulation in individuals suffering from posttraumatic stress disorders

Accelerated ageing and effects of psychotherapy on DNA strand break accumulation in individuals suffering from posttraumatic stress disorders

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Prüfsumme: MD5:fe18a3f3859e4567c49ebb882ec2f069

MORENO-VILLANUEVA, Maria, Julia MORATH, Valerie VANHOOREN, Thomas ELBERT, Claude LIBERT, Alexander BÜRKLE, Iris-Tatjana KOLASSA, 2015. Accelerated ageing and effects of psychotherapy on DNA strand break accumulation in individuals suffering from posttraumatic stress disorders. In: Experimental Gerontology. 68, pp. 104. ISSN 0531-5565. eISSN 1873-6815

@article{Moreno-Villanueva2015Accel-32313, title={Accelerated ageing and effects of psychotherapy on DNA strand break accumulation in individuals suffering from posttraumatic stress disorders}, year={2015}, doi={10.1016/j.exger.2015.01.036}, volume={68}, issn={0531-5565}, journal={Experimental Gerontology}, author={Moreno-Villanueva, Maria and Morath, Julia and Vanhooren, Valerie and Elbert, Thomas and Libert, Claude and Bürkle, Alexander and Kolassa, Iris-Tatjana} }

2015-12-03T07:58:44Z Elbert, Thomas Moreno-Villanueva, Maria Vanhooren, Valerie Morath, Julia Morath, Julia Bürkle, Alexander Libert, Claude Vanhooren, Valerie Accelerated ageing and effects of psychotherapy on DNA strand break accumulation in individuals suffering from posttraumatic stress disorders 2015-12-03T07:58:44Z Bürkle, Alexander eng Kolassa, Iris-Tatjana Moreno-Villanueva, Maria Libert, Claude The prevalence of age-related diseases is increased in individuals with Posttraumatic Stress Disorder (PTSD). At the molecular level, N-Glycosylation is an age-dependent process, identified as a biomarker for physiological aging (GlycoAge Test). Individuals with PTSD and trauma-exposed individuals presented an upward shift in the GlycoAge Test, equivalent to an advancement of the aging process by 15 additional years.<br /><br />On the other hand traumatic stress may increase carcinogenesis via increased DNA damage and impaired DNA repair mechanisms. We found higher levels of basal DNA breakage in individuals with PTSD and trauma-exposed subjects than in controls. However, single-strand break repair was unimpaired in individuals with PTSD.<br /><br />In conclusion, our results suggest that cumulative exposure to traumatic stressors accelerates the process of physiological aging and show – for the first time in vivo – an association between traumatic stress and DNA breakage. Moreover, we demonstrate changes at the molecular level, i.e. the integrity of DNA, after psychotherapeutic interventions. Kolassa, Iris-Tatjana Elbert, Thomas 2015

Dateiabrufe seit 03.12.2015 (Informationen über die Zugriffsstatistik)

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