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α-Thioalkylation of Zinc Dienolates as an Entry to 4-Substituted 1-tert-Butoxy-7a-methylhexahydroindenes

α-Thioalkylation of Zinc Dienolates as an Entry to 4-Substituted 1-tert-Butoxy-7a-methylhexahydroindenes

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KÖHLER, Thomas, Thomas HUHN, Ulrich GROTH, 2015. α-Thioalkylation of Zinc Dienolates as an Entry to 4-Substituted 1-tert-Butoxy-7a-methylhexahydroindenes. In: French-Ukrainian Journal of Chemistry. 3(1), pp. 29-45. eISSN 2312-3222

@article{Kohler2015-Thio-32233, title={α-Thioalkylation of Zinc Dienolates as an Entry to 4-Substituted 1-tert-Butoxy-7a-methylhexahydroindenes}, year={2015}, number={1}, volume={3}, journal={French-Ukrainian Journal of Chemistry}, pages={29--45}, author={Köhler, Thomas and Huhn, Thomas and Groth, Ulrich} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/32233"> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/32233"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-11-24T13:18:14Z</dcterms:available> <dc:language>eng</dc:language> <dcterms:rights rdf:resource="http://nbn-resolving.de/urn:nbn:de:bsz:352-20150914100631302-4485392-8"/> <dcterms:issued>2015</dcterms:issued> <dc:creator>Groth, Ulrich</dc:creator> <dc:contributor>Köhler, Thomas</dc:contributor> <dc:contributor>Groth, Ulrich</dc:contributor> <dcterms:abstract xml:lang="eng">Hexahydroindenes 10 are readily available in 3 steps with an overall yield of 41 – 45 % starting from the Hajos Wiechert ketone 1. Alkylation of the α,β-unsaturated ketone 1 at C-4 has been achieved by thioalkylation of the corresponding zinc dienolate 2 with α-chlorosulfides of type 3. Subsequent in situ reduction and desulfurization of the β-(phenylthio) ketones 4 leads directly to the 4-substituted hexahydroindene-5-ols 6 which can be deoxygenated via their mesylates to the hexahydroindenes 10.</dcterms:abstract> <dc:contributor>Huhn, Thomas</dc:contributor> <dcterms:title>α-Thioalkylation of Zinc Dienolates as an Entry to 4-Substituted 1-tert-Butoxy-7a-methylhexahydroindenes</dcterms:title> <dc:creator>Huhn, Thomas</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-11-24T13:18:14Z</dc:date> <dc:creator>Köhler, Thomas</dc:creator> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 24.11.2015 (Informationen über die Zugriffsstatistik)

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