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Synthesis and X-ray structure analysis of cytotoxic heptacoordinate sulfonamide salan titanium(IV)-bis-chelates

Synthesis and X-ray structure analysis of cytotoxic heptacoordinate sulfonamide salan titanium(IV)-bis-chelates

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ZHAO, Tiankun, Martin GRÜTZKE, Kathrin H. GÖTZ, Tetiana DRUZHENKO, Thomas HUHN, 2015. Synthesis and X-ray structure analysis of cytotoxic heptacoordinate sulfonamide salan titanium(IV)-bis-chelates. In: Dalton Transactions. 44(37), pp. 16475-16485. ISSN 1477-9226. eISSN 1477-9234

@article{Zhao2015-09-15Synth-32224, title={Synthesis and X-ray structure analysis of cytotoxic heptacoordinate sulfonamide salan titanium(IV)-bis-chelates}, year={2015}, doi={10.1039/c5dt01618e}, number={37}, volume={44}, issn={1477-9226}, journal={Dalton Transactions}, pages={16475--16485}, author={Zhao, Tiankun and Grützke, Martin and Götz, Kathrin H. and Druzhenko, Tetiana and Huhn, Thomas} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/32224"> <dc:language>eng</dc:language> <dc:creator>Huhn, Thomas</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.de/urn:nbn:de:bsz:352-20150914100631302-4485392-8"/> <dcterms:title>Synthesis and X-ray structure analysis of cytotoxic heptacoordinate sulfonamide salan titanium(IV)-bis-chelates</dcterms:title> <dc:creator>Götz, Kathrin H.</dc:creator> <dc:creator>Zhao, Tiankun</dc:creator> <dc:creator>Druzhenko, Tetiana</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-11-23T14:49:04Z</dcterms:available> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/32224"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-11-23T14:49:04Z</dc:date> <dc:contributor>Grützke, Martin</dc:contributor> <dcterms:issued>2015-09-15</dcterms:issued> <dc:creator>Grützke, Martin</dc:creator> <dc:contributor>Götz, Kathrin H.</dc:contributor> <dcterms:abstract xml:lang="eng">A series of novel sulfonamide substituted heteroleptic salan titanium(iv)-bis-chelates complexed to 2,6-pyridinedicarboxylic acid were synthesized, structurally characterized and evaluated for their anticancer activity against two human carcinoma cell lines. All cytotoxic complexes showed complete inhibition of cell growth at active concentration, two complexes based on pyrrolidine and azepane substituted sulfonamides displayed IC50 values below 1.7 μM and are more cytotoxic than cisplatin in both tested cell lines. The azepane substituted complex exhibited excellent activity with an IC50 value of 0.5 ± 0.1 μM in Hela S3 and 1.0 ± 0.1 μM in Hep G2.</dcterms:abstract> <dc:contributor>Zhao, Tiankun</dc:contributor> <dc:contributor>Huhn, Thomas</dc:contributor> <dc:contributor>Druzhenko, Tetiana</dc:contributor> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 23.11.2015 (Informationen über die Zugriffsstatistik)

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