Directional Collective Cell Migration Emerges as a Property of Cell Interactions


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WOODS, Mae L., Carlos CARMONA-FONTAINE, Chris P. BARNES, Iain D. COUZIN, Roberto MAYOR, Karen M. PAGE, 2014. Directional Collective Cell Migration Emerges as a Property of Cell Interactions. In: PLoS ONE. 9(9), e104969. eISSN 1932-6203. Available under: doi: 10.1371/journal.pone.0104969

@article{Woods2014Direc-31326, title={Directional Collective Cell Migration Emerges as a Property of Cell Interactions}, year={2014}, doi={10.1371/journal.pone.0104969}, number={9}, volume={9}, journal={PLoS ONE}, author={Woods, Mae L. and Carmona-Fontaine, Carlos and Barnes, Chris P. and Couzin, Iain D. and Mayor, Roberto and Page, Karen M.}, note={Article Number: e104969} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dc:creator>Couzin, Iain D.</dc:creator> <dcterms:abstract xml:lang="eng">Collective cell migration is a fundamental process, occurring during embryogenesis and cancer metastasis. Neural crest cells exhibit such coordinated migration, where aberrant motion can lead to fatality or dysfunction of the embryo. Migration involves at least two complementary mechanisms: contact inhibition of locomotion (a repulsive interaction corresponding to a directional change of migration upon contact with a reciprocating cell), and co-attraction (a mutual chemoattraction mechanism). Here, we develop and employ a parameterized discrete element model of neural crest cells, to investigate how these mechanisms contribute to long-range directional migration during development. Motion is characterized using a coherence parameter and the time taken to reach, collectively, a target location. The simulated cell group is shown to switch from a diffusive to a persistent state as the response-rate to co-attraction is increased. Furthermore, the model predicts that when co-attraction is inhibited, neural crest cells can migrate into restrictive regions. Indeed, inhibition of co-attraction in vivo and in vitro leads to cell invasion into restrictive areas, confirming the prediction of the model. This suggests that the interplay between the complementary mechanisms may contribute to guidance of the neural crest. We conclude that directional migration is a system property and does not require action of external chemoattractants.</dcterms:abstract> <dspace:hasBitstream rdf:resource=""/> <dcterms:issued>2014</dcterms:issued> <dc:contributor>Mayor, Roberto</dc:contributor> <dcterms:isPartOf rdf:resource=""/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:available rdf:datatype="">2015-07-01T03:38:12Z</dcterms:available> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:language>eng</dc:language> <dc:contributor>Couzin, Iain D.</dc:contributor> <bibo:uri rdf:resource=""/> <dc:creator>Carmona-Fontaine, Carlos</dc:creator> <dc:creator>Page, Karen M.</dc:creator> <dc:creator>Barnes, Chris P.</dc:creator> <dcterms:hasPart rdf:resource=""/> <dspace:isPartOfCollection rdf:resource=""/> <dc:contributor>Barnes, Chris P.</dc:contributor> <dc:contributor>Carmona-Fontaine, Carlos</dc:contributor> <dc:date rdf:datatype="">2015-07-01T03:38:12Z</dc:date> <dcterms:title>Directional Collective Cell Migration Emerges as a Property of Cell Interactions</dcterms:title> <dc:contributor>Woods, Mae L.</dc:contributor> <dc:rights>terms-of-use</dc:rights> <dc:contributor>Page, Karen M.</dc:contributor> <dc:creator>Woods, Mae L.</dc:creator> <dc:creator>Mayor, Roberto</dc:creator> <dcterms:rights rdf:resource=""/> </rdf:Description> </rdf:RDF>

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