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The ChemScreen project to design a pragmatic alternative approach to predict reproductive toxicity of chemicals

The ChemScreen project to design a pragmatic alternative approach to predict reproductive toxicity of chemicals

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Prüfsumme: MD5:338225a08098a93045b5cd751f0bdea1

VAN DER BURG, Bart, Eva Bay WEDEBYE, Daniel R. DIETRICH, Joanna JAWORSKA, Inge MANGELSDORF, Eduard PAUNE, Michael SCHWARZ, Aldert H. PIERSMA, E. Dinant KROESE, 2015. The ChemScreen project to design a pragmatic alternative approach to predict reproductive toxicity of chemicals. In: Reproductive Toxicology. 55, pp. 114-123. ISSN 0890-6238. eISSN 1873-1708

@article{van der Burg2015-08-01ChemS-31181, title={The ChemScreen project to design a pragmatic alternative approach to predict reproductive toxicity of chemicals}, year={2015}, doi={10.1016/j.reprotox.2015.01.008}, volume={55}, issn={0890-6238}, journal={Reproductive Toxicology}, pages={114--123}, author={van der Burg, Bart and Wedebye, Eva Bay and Dietrich, Daniel R. and Jaworska, Joanna and Mangelsdorf, Inge and Paune, Eduard and Schwarz, Michael and Piersma, Aldert H. and Kroese, E. Dinant} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/31181"> <dc:creator>Kroese, E. Dinant</dc:creator> <dc:contributor>Piersma, Aldert H.</dc:contributor> <dc:contributor>Jaworska, Joanna</dc:contributor> <dc:creator>van der Burg, Bart</dc:creator> <dcterms:issued>2015-08-01</dcterms:issued> <dc:creator>Schwarz, Michael</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/31181"/> <dc:contributor>Paune, Eduard</dc:contributor> <dc:creator>Piersma, Aldert H.</dc:creator> <dc:creator>Jaworska, Joanna</dc:creator> <dc:creator>Mangelsdorf, Inge</dc:creator> <dc:contributor>Wedebye, Eva Bay</dc:contributor> <dcterms:title>The ChemScreen project to design a pragmatic alternative approach to predict reproductive toxicity of chemicals</dcterms:title> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-06-17T13:28:50Z</dc:date> <dc:language>eng</dc:language> <dc:creator>Wedebye, Eva Bay</dc:creator> <dcterms:abstract xml:lang="eng">There is a great need for rapid testing strategies for reproductive toxicity testing, avoiding animal use. The EU Framework program 7 project ChemScreen aimed to fill this gap in a pragmatic manner preferably using validated existing tools and place them in an innovative alternative testing strategy. In our approach we combined knowledge on critical processes affected by reproductive toxicants with knowledge on the mechanistic basis of such effects. We used in silico methods for prescreening chemicals for relevant toxic effects aiming at reduced testing needs. For those chemicals that need testing we have set up an in vitro screening panel that includes mechanistic high throughput methods and lower throughput assays that measure more integrative endpoints. In silico pharmacokinetic modules were developed for rapid exposure predictions via diverse exposure routes. These modules to match in vitro and in vivo exposure levels greatly improved predictivity of the in vitro tests. As a further step, we have generated examples how to predict reproductive toxicity of chemicals using available data. We have executed formal validations of panel constituents and also used more innovative manners to validate the test panel using mechanistic approaches. We are actively engaged in promoting regulatory acceptance of the tools developed as an essential step towards practical application, including case studies for read-across purposes. With this approach, a significant saving in animal use and associated costs seems very feasible.</dcterms:abstract> <dc:contributor>van der Burg, Bart</dc:contributor> <dc:contributor>Dietrich, Daniel R.</dc:contributor> <dc:contributor>Schwarz, Michael</dc:contributor> <dc:creator>Dietrich, Daniel R.</dc:creator> <dc:creator>Paune, Eduard</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-06-17T13:28:50Z</dcterms:available> <dcterms:rights rdf:resource="http://nbn-resolving.de/urn:nbn:de:bsz:352-20150914100631302-4485392-8"/> <dc:contributor>Kroese, E. Dinant</dc:contributor> <dc:contributor>Mangelsdorf, Inge</dc:contributor> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 17.06.2015 (Informationen über die Zugriffsstatistik)

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