On the move : endocytic trafficking in cell migration


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MARITZEN, Tanja, Hannah SCHACHTNER, Daniel F. LEGLER, 2015. On the move : endocytic trafficking in cell migration. In: Cellular and Molecular Life Sciences. 72(11), pp. 2119-2134. ISSN 1420-682X. eISSN 1420-9071

@article{Maritzen2015endoc-31088, title={On the move : endocytic trafficking in cell migration}, year={2015}, doi={10.1007/s00018-015-1855-9}, number={11}, volume={72}, issn={1420-682X}, journal={Cellular and Molecular Life Sciences}, pages={2119--2134}, author={Maritzen, Tanja and Schachtner, Hannah and Legler, Daniel F.} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/31088"> <dc:contributor>Schachtner, Hannah</dc:contributor> <dcterms:title>On the move : endocytic trafficking in cell migration</dcterms:title> <dc:contributor>Legler, Daniel F.</dc:contributor> <dc:creator>Legler, Daniel F.</dc:creator> <dc:creator>Maritzen, Tanja</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-06-02T07:24:35Z</dcterms:available> <dc:contributor>Maritzen, Tanja</dc:contributor> <dcterms:issued>2015</dcterms:issued> <dcterms:abstract xml:lang="eng">Directed cell migration is a fundamental process underlying diverse physiological and pathophysiological phenomena ranging from wound healing and induction of immune responses to cancer metastasis. Recent advances reveal that endocytic trafficking contributes to cell migration in multiple ways. (1) At the level of chemokines and chemokine receptors: internalization of chemokines by scavenger receptors is essential for shaping chemotactic gradients in tissue, whereas endocytosis of chemokine receptors and their subsequent recycling is key for maintaining a high responsiveness of migrating cells. (2) At the level of integrin trafficking and focal adhesion dynamics: endosomal pathways do not only modulate adhesion by delivering integrins to their site of action, but also by supplying factors for focal adhesion disassembly. (3) At the level of extracellular matrix reorganization: endosomal transport contributes to tumor cell migration not only by targeting integrins to invadosomes but also by delivering membrane type 1 matrix metalloprotease to the leading edge facilitating proteolysis-dependent chemotaxis. Consequently, numerous endocytic and endosomal factors have been shown to modulate cell migration. In fact key modulators of endocytic trafficking turn out to be also key regulators of cell migration. This review will highlight the recent progress in unraveling the contribution of cellular trafficking pathways to cell migration.</dcterms:abstract> <dcterms:rights rdf:resource="http://nbn-resolving.de/urn:nbn:de:bsz:352-20150914100631302-4485392-8"/> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/31088"/> <dc:language>eng</dc:language> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-06-02T07:24:35Z</dc:date> <dc:creator>Schachtner, Hannah</dc:creator> </rdf:Description> </rdf:RDF>

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