Programmable Sensors of 5-Hydroxymethylcytosine


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KUBIK, Grzegorz, Sabrina BATKE, Daniel SUMMERER, 2015. Programmable Sensors of 5-Hydroxymethylcytosine. In: Journal of the American Chemical Society : JACS. 137(1), pp. 2-5. ISSN 0002-7863. eISSN 1520-5126

@article{Kubik2015Progr-30896, title={Programmable Sensors of 5-Hydroxymethylcytosine}, year={2015}, doi={10.1021/ja506022t}, number={1}, volume={137}, issn={0002-7863}, journal={Journal of the American Chemical Society : JACS}, pages={2--5}, author={Kubik, Grzegorz and Batke, Sabrina and Summerer, Daniel} }

<rdf:RDF xmlns:rdf="" xmlns:bibo="" xmlns:dc="" xmlns:dcterms="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dc:creator>Kubik, Grzegorz</dc:creator> <dcterms:abstract xml:lang="eng">5-Hydroxymethylcytosine (hmC), the sixth base of the mammalian genome, is increasingly recognized as an epigenetic mark with important biological functions. We report engineered, programmable transcription-activator-like effectors (TALEs) as the first DNA-binding receptor molecules that provide direct, individual selectivities for cytosine (C), 5-methylcytosine (mC), and hmC at user-defined DNA sequences. Given the wide applicability of TALEs for programmable targeting of DNA sequences in vitro and in vivo, this provides broad perspectives for epigenetic research.</dcterms:abstract> <dc:date rdf:datatype="">2015-05-06T09:49:04Z</dc:date> <dc:contributor>Batke, Sabrina</dc:contributor> <dc:creator>Batke, Sabrina</dc:creator> <dc:contributor>Summerer, Daniel</dc:contributor> <dcterms:title>Programmable Sensors of 5-Hydroxymethylcytosine</dcterms:title> <bibo:uri rdf:resource=""/> <dc:language>eng</dc:language> <dcterms:issued>2015</dcterms:issued> <dc:creator>Summerer, Daniel</dc:creator> <dcterms:available rdf:datatype="">2015-05-06T09:49:04Z</dcterms:available> <dc:contributor>Kubik, Grzegorz</dc:contributor> </rdf:Description> </rdf:RDF>

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