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Analgesia in mice with experimental meningitis reduces pain without altering immune parameters

Analgesia in mice with experimental meningitis reduces pain without altering immune parameters

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MUNDT, Sarah, Marcus GRÖTTRUP, Michael BASLER, 2015. Analgesia in mice with experimental meningitis reduces pain without altering immune parameters. In: Alternatives to animal experimentation : Altex. 32(3), pp. 183-189. ISSN 1868-596X. eISSN 1868-8551. Available under: doi: 10.14573/altex.1502021

@article{Mundt2015Analg-30789, title={Analgesia in mice with experimental meningitis reduces pain without altering immune parameters}, year={2015}, doi={10.14573/altex.1502021}, number={3}, volume={32}, issn={1868-596X}, journal={Alternatives to animal experimentation : Altex}, pages={183--189}, author={Mundt, Sarah and Gröttrup, Marcus and Basler, Michael} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/30789"> <dc:creator>Basler, Michael</dc:creator> <dc:language>eng</dc:language> <dc:rights>terms-of-use</dc:rights> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-04-21T07:08:29Z</dcterms:available> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/30789/1/Mundt_0-284168.pdf"/> <dcterms:title>Analgesia in mice with experimental meningitis reduces pain without altering immune parameters</dcterms:title> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/30789"/> <dc:creator>Gröttrup, Marcus</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Mundt, Sarah</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-04-21T07:08:29Z</dc:date> <dc:contributor>Mundt, Sarah</dc:contributor> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/30789/1/Mundt_0-284168.pdf"/> <dcterms:rights rdf:resource="https://kops.uni-konstanz.de/page/termsofuse"/> <dcterms:abstract xml:lang="eng">Intracranial lymphocytic choriomeningitis virus (LCMV) infection is a widely used animal model to study virus-induced cytotoxic T cell (CTL) mediated meningitis and immunopathology. Nevertheless, this model causes severe pain and distress in mice, especially at later stages of the disease. Therefore, new treatment regimens to improve animal welfare have to be developed. In this study, we subcutaneously implanted ALZET® osmotic pumps continuously releasing buprenorphine to reduce pain in mice with LCMV-induced meningitis. Thereby, mice treated with buprenorphine demonstrated strongly reduced symptoms of pain. However, the LCMV-specific cytotoxic T cell response and the immune cell infiltration into the central nervous system (CNS) were unchanged in analgesia treated mice indicating that the LCMV-induced immune response was not altered in these mice. Taken together, we demonstrate that in this animal model for meningitis continuous buprenorphine treatment improves animal welfare without affecting the immune response.</dcterms:abstract> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Gröttrup, Marcus</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Basler, Michael</dc:contributor> <dcterms:issued>2015</dcterms:issued> </rdf:Description> </rdf:RDF>

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