Type of Publication: | Journal article |
URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-0-285500 |
Author: | Rovida, Costanza; Daneshian, Mardas; Hartung, Thomas |
Year of publication: | 2015 |
Published in: | Alternatives to animal experimentation : ALTEX ; 32 (2015), 1. - pp. 25-40. - ISSN 1868-596X. - eISSN 1868-8551 |
DOI (citable link): | https://dx.doi.org/10.14573/altex.1411011 |
Summary: |
Integrated testing strategies (ITS), as opposed to a single definitive test or fixed batteries of tests, are expected to efficiently combine different information sources in a quantifiable fashion to satisfy an information need, in this case for regulatory safety assessments. With increasing awareness of the limitations of each individual tool and the development of highly targeted tests and predictions, the need for combining pieces of evidence increases. The discussions that took place during this workshop, which brought together a group of experts coming from different related areas, illustrate the current state of the art of ITS, as well as promising developments and identifiable challenges. The case of skin sensitization was taken as an example to understand how possible ITS can be constructed, optimized and validated. This will require embracing and developing new concepts such as adverse outcome pathways (AOP), advanced statistical learning algorithms and machine learning, mechanistic validation and “Good ITS Practices”.
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Subject (DDC): | 540 Chemistry |
Keywords: | in vitro methods, testing strategy, Tox21c, skin sensitization, computational toxicology |
Link to License: | In Copyright |
Bibliography of Konstanz: | Yes |
ROVIDA, Costanza, Mardas DANESHIAN, Thomas HARTUNG, 2015. Integrated Testing Strategies (ITS) for safety assessment. In: Alternatives to animal experimentation : ALTEX. 32(1), pp. 25-40. ISSN 1868-596X. eISSN 1868-8551. Available under: doi: 10.14573/altex.1411011
@article{Rovida2015Integ-30736, title={Integrated Testing Strategies (ITS) for safety assessment}, year={2015}, doi={10.14573/altex.1411011}, number={1}, volume={32}, issn={1868-596X}, journal={Alternatives to animal experimentation : ALTEX}, pages={25--40}, author={Rovida, Costanza and Daneshian, Mardas and Hartung, Thomas} }
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Rovida_0-285500.pdf | 2359 |