Achieving Single-Nucleotide Resolution of 5-Methylcytosine Detection with TALEs

Zitieren

Dateien zu dieser Ressource

Dateien Größe Format Anzeige

Zu diesem Dokument gibt es keine Dateien.

KUBIK, Grzegorz, Daniel SUMMERER, 2015. Achieving Single-Nucleotide Resolution of 5-Methylcytosine Detection with TALEs. In: ChemBioChem. 16(2), pp. 228-231. ISSN 1439-4227. eISSN 1439-7633

@article{Kubik2015Achie-30723, title={Achieving Single-Nucleotide Resolution of 5-Methylcytosine Detection with TALEs}, year={2015}, doi={10.1002/cbic.201402408}, number={2}, volume={16}, issn={1439-4227}, journal={ChemBioChem}, pages={228--231}, author={Kubik, Grzegorz and Summerer, Daniel} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/30723"> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-04-13T08:08:58Z</dcterms:available> <dcterms:issued>2015</dcterms:issued> <dc:creator>Summerer, Daniel</dc:creator> <dc:contributor>Summerer, Daniel</dc:contributor> <dc:language>eng</dc:language> <dcterms:abstract xml:lang="eng">We report engineered transcription-activator-like effectors (TALEs) as the first DNA-binding molecules that detect 5-methylcytosine (mC) at single-nucleotide resolution with fully programmable sequence selectivity. This is achieved by a design strategy such that a single cytosine (C) in a DNA sequence is selectively interrogated for its mC-modification level by targeting with a discriminatory TALE repeat; other Cs are ignored by targeting with universal-binding TALE repeats.</dcterms:abstract> <dc:contributor>Kubik, Grzegorz</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/30723"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-04-13T08:08:58Z</dc:date> <dc:creator>Kubik, Grzegorz</dc:creator> <dcterms:title>Achieving Single-Nucleotide Resolution of 5-Methylcytosine Detection with TALEs</dcterms:title> </rdf:Description> </rdf:RDF>

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto