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A genotype-specific, randomized controlled behavioral intervention to improve the neuroemotional outcome of cardiac surgery : study protocol for a randomized controlled trial

A genotype-specific, randomized controlled behavioral intervention to improve the neuroemotional outcome of cardiac surgery : study protocol for a randomized controlled trial

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Prüfsumme: MD5:5e50ed52e1e60da7719d5ebb613ad19d

HAUER, Daniela, Iris-Tatjana KOLASSA, Rüdiger Paul LAUBENDER, Ulrich MANSMANN, Christian HAGL, Benno ROOZENDAAL, Dominique J.-F. DE QUERVAIN, Gustav SCHELLING, 2013. A genotype-specific, randomized controlled behavioral intervention to improve the neuroemotional outcome of cardiac surgery : study protocol for a randomized controlled trial. In: Trials. 14, 89. ISSN 1468-6708. eISSN 1745-6215

@article{Hauer2013genot-30593, title={A genotype-specific, randomized controlled behavioral intervention to improve the neuroemotional outcome of cardiac surgery : study protocol for a randomized controlled trial}, year={2013}, doi={10.1186/1745-6215-14-89}, volume={14}, issn={1468-6708}, journal={Trials}, author={Hauer, Daniela and Kolassa, Iris-Tatjana and Laubender, Rüdiger Paul and Mansmann, Ulrich and Hagl, Christian and Roozendaal, Benno and de Quervain, Dominique J.-F. and Schelling, Gustav}, note={Article Number: 89} }

Mansmann, Ulrich de Quervain, Dominique J.-F. Laubender, Rüdiger Paul Hauer, Daniela Kolassa, Iris-Tatjana 2015-03-30T08:24:01Z Schelling, Gustav Roozendaal, Benno Mansmann, Ulrich Hagl, Christian Hagl, Christian 2015-03-30T08:24:01Z Laubender, Rüdiger Paul Kolassa, Iris-Tatjana Roozendaal, Benno de Quervain, Dominique J.-F. eng Cardiac surgery is one of the most commonly performed surgical procedures worldwide with >700,000 surgeries in 2006 in the US alone. Cardiac surgery results in a considerable exposure to physical and emotional stress; stress-related disorders such as depression or post-traumatic stress disorder are the most common adverse outcomes of cardiac surgery, seen in up to 20% of patients. Using information from a genome-wide association study to characterize genetic effects on emotional memory, we recently identified a single nucleotide polymorphism of the glucocorticoid receptor gene (the Bcll single nucleotide polymorphism) as a significant genetic risk factor for traumatic memories from cardiac surgery and symptoms of post-traumaticstress disorder. The Bcll high-risk genotype (Bcll GG) has a prevalence of 16.6% in patients undergoing cardiac surgery and is associated with increased glucocorticoid receptor signaling under stress. Concomitant animal experiments have confirmed an essential role of glucocorticoid receptor activation for traumatic memory formation during stressful experiences. Early cognitive behavioral intervention has been shown to prevent stress-related disorders after heart surgery. A genotype-specific, randomized controlled behavioral intervention to improve the neuroemotional outcome of cardiac surgery : study protocol for a randomized controlled trial Hauer, Daniela Schelling, Gustav 2013

Dateiabrufe seit 30.03.2015 (Informationen über die Zugriffsstatistik)

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