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Sweet Taste and Nutrient Value Subdivide Rewarding Dopaminergic Neurons in Drosophila

Sweet Taste and Nutrient Value Subdivide Rewarding Dopaminergic Neurons in Drosophila

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HUETTEROTH, Wolf, Emmanuel PERISSE, Suewei LIN, Martín KLAPPENBACH, Christopher BURKE, Scott WADDELL, 2015. Sweet Taste and Nutrient Value Subdivide Rewarding Dopaminergic Neurons in Drosophila. In: Current Biology. 25(6), pp. 751-758. ISSN 0960-9822. eISSN 1879-0445

@article{Huetteroth2015Sweet-30445, title={Sweet Taste and Nutrient Value Subdivide Rewarding Dopaminergic Neurons in Drosophila}, year={2015}, doi={10.1016/j.cub.2015.01.036}, number={6}, volume={25}, issn={0960-9822}, journal={Current Biology}, pages={751--758}, author={Huetteroth, Wolf and Perisse, Emmanuel and Lin, Suewei and Klappenbach, Martín and Burke, Christopher and Waddell, Scott} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/30445"> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-03-20T08:31:30Z</dc:date> <dc:contributor>Huetteroth, Wolf</dc:contributor> <dc:contributor>Waddell, Scott</dc:contributor> <dc:creator>Klappenbach, Martín</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:creator>Burke, Christopher</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/30445"/> <dcterms:abstract xml:lang="eng">Dopaminergic neurons provide reward learning signals in mammals and insects [1-4]. Recent work in Drosophila has demonstrated that water-reinforcing dopaminergic neurons are different to those for nutritious sugars [5]. Here, we tested whether the sweet taste and nutrient properties of sugar reinforcement further subdivide the fly reward system. We found that dopaminergic neurons expressing the OAMB octopamine receptor [6] specifically convey the short-term reinforcing effects of sweet taste [4]. These dopaminergic neurons project to the β'2 and γ4 regions of the mushroom body lobes. In contrast, nutrient-dependent long-term memory requires different dopaminergic neurons that project to the γ5b regions, and it can be artificially reinforced by those projecting to the β lobe and adjacent α1 region. Surprisingly, whereas artificial implantation and expression of short-term memory occur in satiated flies, formation and expression of artificial long-term memory require flies to be hungry. These studies suggest that short-term and long-term sugar memories have different physiological constraints. They also demonstrate further functional heterogeneity within the rewarding dopaminergic neuron population.</dcterms:abstract> <dcterms:issued>2015</dcterms:issued> <dc:language>eng</dc:language> <dc:creator>Waddell, Scott</dc:creator> <dc:creator>Lin, Suewei</dc:creator> <dcterms:title>Sweet Taste and Nutrient Value Subdivide Rewarding Dopaminergic Neurons in Drosophila</dcterms:title> <dc:creator>Huetteroth, Wolf</dc:creator> <dc:contributor>Klappenbach, Martín</dc:contributor> <dc:contributor>Lin, Suewei</dc:contributor> <dc:contributor>Perisse, Emmanuel</dc:contributor> <dc:creator>Perisse, Emmanuel</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-03-20T08:31:30Z</dcterms:available> <dc:contributor>Burke, Christopher</dc:contributor> </rdf:Description> </rdf:RDF>

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