Subunit specific inhibitors of proteasomes and their potential for immunomodulation

Kisselev, Alexei F.; Gröttrup, Marcus

Subunit specific inhibitors of proteasomes and their potential for immunomodulation

Files

Kisselev_0-264534.pdf(801.6 KB)

Date

2014

Authors

Kisselev, Alexei F.

Gröttrup, Marcus

Publication type

Journal article

Published in

Current Opinion in Chemical Biology ; 23 (2014). - pp. 16-22. - ISSN 1367-5931. - eISSN 1879-0402

Abstract

Specialized variants of the constitutive 20S proteasome in the immune system like the immunoproteasomes and the thymoproteasome contain active site-bearing subunits which differ in their cleavage priorities and substrate binding pockets. The immunoproteasome plays a crucial role in antigen processing and for the differentiation of pro-inflammatory T helper cells which are involved in the pathogenesis of autoimmunity. Selective inhibitors of the immunoproteasome and constitutive proteasome have recently been generated which interfere with the development and progression of autoimmune diseases. Here we describe these inhibitors and their therapeutic potential as predicted from preclinical models.

Subject (DDC)

570 Biosciences, Biology

Cite This

ISO 690

KISSELEV, Alexei F., Marcus GRÖTTRUP, 2014. Subunit specific inhibitors of proteasomes and their potential for immunomodulation. In: Current Opinion in Chemical Biology. 23, pp. 16-22. ISSN 1367-5931. eISSN 1879-0402. Available under: doi: 10.1016/j.cbpa.2014.08.012

BibTex

@article{Kisselev2014Subun-29806,
  year={2014},
  doi={10.1016/j.cbpa.2014.08.012},
  title={Subunit specific inhibitors of proteasomes and their potential for immunomodulation},
  volume={23},
  issn={1367-5931},
  journal={Current Opinion in Chemical Biology},
  pages={16--22},
  author={Kisselev, Alexei F. and Gröttrup, Marcus}
}

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Bibliography of Konstanz

Yes