Subunit specific inhibitors of proteasomes and their potential for immunomodulation
Aufgrund von Vorbereitungen auf eine neue Version von KOPS, können am Montag, 6.2. und Dienstag, 7.2. keine Publikationen eingereicht werden. (Due to preparations for a new version of KOPS, no publications can be submitted on Monday, Feb. 6 and Tuesday, Feb. 7.)
| Type of Publication: | Journal article |
| URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-0-264534 |
| Author: | Kisselev, Alexei F.; Groettrup, Marcus |
| Year of publication: | 2014 |
| Published in: | Current Opinion in Chemical Biology ; 23 (2014). - pp. 16-22. - ISSN 1367-5931. - eISSN 1879-0402 |
| Pubmed ID: | 25217863 |
| DOI (citable link): | https://dx.doi.org/10.1016/j.cbpa.2014.08.012 |
| Summary: |
Specialized variants of the constitutive 20S proteasome in the immune system like the immunoproteasomes and the thymoproteasome contain active site-bearing subunits which differ in their cleavage priorities and substrate binding pockets. The immunoproteasome plays a crucial role in antigen processing and for the differentiation of pro-inflammatory T helper cells which are involved in the pathogenesis of autoimmunity. Selective inhibitors of the immunoproteasome and constitutive proteasome have recently been generated which interfere with the development and progression of autoimmune diseases. Here we describe these inhibitors and their therapeutic potential as predicted from preclinical models.
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| Subject (DDC): | 570 Biosciences, Biology |
| Link to License: | In Copyright |
| Bibliography of Konstanz: | Yes |
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KISSELEV, Alexei F., Marcus GROETTRUP, 2014. Subunit specific inhibitors of proteasomes and their potential for immunomodulation. In: Current Opinion in Chemical Biology. 23, pp. 16-22. ISSN 1367-5931. eISSN 1879-0402. Available under: doi: 10.1016/j.cbpa.2014.08.012
@article{Kisselev2014Subun-29806, title={Subunit specific inhibitors of proteasomes and their potential for immunomodulation}, year={2014}, doi={10.1016/j.cbpa.2014.08.012}, volume={23}, issn={1367-5931}, journal={Current Opinion in Chemical Biology}, pages={16--22}, author={Kisselev, Alexei F. and Groettrup, Marcus} }
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