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Subunit specific inhibitors of proteasomes and their potential for immunomodulation

Subunit specific inhibitors of proteasomes and their potential for immunomodulation

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Prüfsumme: MD5:52b901345976f50d6f4f4cf988a56397

KISSELEV, Alexei F., Marcus GROETTRUP, 2014. Subunit specific inhibitors of proteasomes and their potential for immunomodulation. In: Current Opinion in Chemical Biology. 23, pp. 16-22. ISSN 1367-5931. eISSN 1879-0402

@article{Kisselev2014Subun-29806, title={Subunit specific inhibitors of proteasomes and their potential for immunomodulation}, year={2014}, doi={10.1016/j.cbpa.2014.08.012}, volume={23}, issn={1367-5931}, journal={Current Opinion in Chemical Biology}, pages={16--22}, author={Kisselev, Alexei F. and Groettrup, Marcus} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/29806"> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-02-09T10:44:13Z</dcterms:available> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/29806"/> <dc:language>eng</dc:language> <dcterms:issued>2014</dcterms:issued> <dc:contributor>Groettrup, Marcus</dc:contributor> <dcterms:abstract xml:lang="eng">Specialized variants of the constitutive 20S proteasome in the immune system like the immunoproteasomes and the thymoproteasome contain active site-bearing subunits which differ in their cleavage priorities and substrate binding pockets. The immunoproteasome plays a crucial role in antigen processing and for the differentiation of pro-inflammatory T helper cells which are involved in the pathogenesis of autoimmunity. Selective inhibitors of the immunoproteasome and constitutive proteasome have recently been generated which interfere with the development and progression of autoimmune diseases. Here we describe these inhibitors and their therapeutic potential as predicted from preclinical models.</dcterms:abstract> <dcterms:rights rdf:resource="http://nbn-resolving.de/urn:nbn:de:bsz:352-20150914100631302-4485392-8"/> <dcterms:title>Subunit specific inhibitors of proteasomes and their potential for immunomodulation</dcterms:title> <dc:creator>Kisselev, Alexei F.</dc:creator> <dc:contributor>Kisselev, Alexei F.</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-02-09T10:44:13Z</dc:date> <dc:creator>Groettrup, Marcus</dc:creator> </rdf:Description> </rdf:RDF>

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