@article{Kuebler2015-05Stres-29657,
  year={2015},
  doi={10.1016/j.bbi.2014.12.024},
  title={Stress-induced modulation of NF-κB activation, inflammation-associated gene expression, and cytokine levels in blood of healthy men},
  volume={46},
  issn={0889-1591},
  journal={Brain, Behavior and Immunity},
  pages={87--95},
  author={Kuebler, Ulrike and Zuccarella-Hackl, Claudia and Arpagaus, Angela and Wolf, Jutta M. and Farahmand, Firouzeh and von Känel, Roland and Ehlert, Ulrike and Wirtz, Petra H.}
}

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    <dc:contributor>Wolf, Jutta M.</dc:contributor>
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    <dc:contributor>Wirtz, Petra H.</dc:contributor>
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    <dc:creator>von Känel, Roland</dc:creator>
    <dc:contributor>Ehlert, Ulrike</dc:contributor>
    <dcterms:issued>2015-05</dcterms:issued>
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    <dc:contributor>von Känel, Roland</dc:contributor>
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    <dc:creator>Ehlert, Ulrike</dc:creator>
    <dcterms:title>Stress-induced modulation of NF-κB activation, inflammation-associated gene expression, and cytokine levels in blood of healthy men</dcterms:title>
    <dc:contributor>Kuebler, Ulrike</dc:contributor>
    <dc:creator>Arpagaus, Angela</dc:creator>
    <dc:creator>Wirtz, Petra H.</dc:creator>
    <dc:contributor>Zuccarella-Hackl, Claudia</dc:contributor>
    <dcterms:abstract xml:lang="eng">Acute psychosocial stress stimulates transient increases in circulating pro-inflammatory plasma cytokines, but little is known about stress effects on anti-inflammatory cytokines or underlying mechanisms. We investigated the stress kinetics and interrelations of pro- and anti-inflammatory measures on the transcriptional and protein level.&lt;br /&gt;&lt;br /&gt;Forty-five healthy men were randomly assigned to either a stress or control group. While the stress group underwent an acute psychosocial stress task, the second group participated in a non-stress control condition. We repeatedly measured before and up to 120 min after stress DNA binding activity of the pro-inflammatory transcription factor NF-κB (NF-κB-BA) in peripheral blood mononuclear cells, whole-blood mRNA levels of NF-κB, its inhibitor IκBα, and of the pro-inflammatory cytokines interleukin (IL)-1ß and IL-6, and the anti-inflammatory cytokine IL-10. We also repeatedly measured plasma levels of IL-1ß, IL-6, and IL-10.&lt;br /&gt;&lt;br /&gt;Compared to non-stress, acute stress induced significant and rapid increases in NF-κB-BA and delayed increases in plasma IL-6 and mRNA of IL-1ß, IL-6, and IκBα (p’s &lt; .045). In the stress group, significant increases over time were also observed for NF-κB mRNA and plasma IL-1ß and IL-10 (p’s &lt; .055). NF-κB-BA correlated significantly with mRNA of IL-1β (r = .52, p = .002), NF-κB (r = .48, p = .004), and IκBα (r = .42, p = .013), and marginally with IL-6 mRNA (r = .31, p = .11). Plasma cytokines did not relate to NF-κB-BA or mRNA levels of the respective cytokines.&lt;br /&gt;&lt;br /&gt;Our data suggest that stress induces increases in NF-κB-BA that relate to subsequent mRNA expression of pro-inflammatory, but not anti-inflammatory cytokines, and of regulatory-cytoplasmic-proteins. The stress-induced increases in plasma cytokines do not seem to derive from de novo synthesis in circulating blood cells.</dcterms:abstract>
    <dc:creator>Zuccarella-Hackl, Claudia</dc:creator>
    <dc:contributor>Arpagaus, Angela</dc:contributor>
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    <dc:creator>Kuebler, Ulrike</dc:creator>
    <dc:creator>Wolf, Jutta M.</dc:creator>
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