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Lipid droplet and early autophagosomal membrane targeting of Atg2A and Atg14L in human tumor cells

Lipid droplet and early autophagosomal membrane targeting of Atg2A and Atg14L in human tumor cells

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PFISTERER, Simon G., Daniela BAKULA, Tancred FRICKEY, Alice CEZANNE, Daniel BRIGGER, Mario P. TSCHAN, Horst ROBENEK, Tassula PROIKAS-CEZANNE, 2014. Lipid droplet and early autophagosomal membrane targeting of Atg2A and Atg14L in human tumor cells. In: Journal of Lipid Research. 55, pp. 1267-1278. ISSN 0022-2275. eISSN 1539-7262

@article{Pfisterer2014Lipid-29636, title={Lipid droplet and early autophagosomal membrane targeting of Atg2A and Atg14L in human tumor cells}, year={2014}, doi={10.1194/jlr.M046359}, volume={55}, issn={0022-2275}, journal={Journal of Lipid Research}, pages={1267--1278}, author={Pfisterer, Simon G. and Bakula, Daniela and Frickey, Tancred and Cezanne, Alice and Brigger, Daniel and Tschan, Mario P. and Robenek, Horst and Proikas-Cezanne, Tassula} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/29636"> <dc:language>eng</dc:language> <dc:creator>Tschan, Mario P.</dc:creator> <dc:creator>Proikas-Cezanne, Tassula</dc:creator> <dc:creator>Robenek, Horst</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-01-26T18:33:12Z</dc:date> <dc:contributor>Frickey, Tancred</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/29636"/> <dc:contributor>Brigger, Daniel</dc:contributor> <dc:creator>Brigger, Daniel</dc:creator> <dc:contributor>Bakula, Daniela</dc:contributor> <dc:contributor>Robenek, Horst</dc:contributor> <dcterms:issued>2014</dcterms:issued> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-01-26T18:33:12Z</dcterms:available> <dc:creator>Frickey, Tancred</dc:creator> <dcterms:abstract xml:lang="eng">Autophagy is a lysosomal bulk degradation pathway for cytoplasmic cargo, such as long-lived proteins, lipids, and organelles. Induced upon nutrient starvation, autophagic degradation is accomplished by the concerted actions of autophagy-related (ATG) proteins. Here we demonstrate that two ATGs, human Atg2A and Atg14L, colocalize at cytoplasmic lipid droplets (LDs) and are functionally involved in controlling the number and size of LDs in human tumor cell lines. We show that Atg2A is targeted to cytoplasmic ADRP-positive LDs that migrate bidirectionally along microtubules. The LD localization of Atg2A was found to be independent of the autophagic status. Further, Atg2A colocalized with Atg14L under nutrient-rich conditions when autophagy was not induced. Upon nutrient starvation and dependent on phosphatidylinositol 3-phosphate [PtdIns(3)P] generation, both Atg2A and Atg14L were also specifically targeted to endoplasmic reticulum-associated early autophagosomal membranes, marked by the PtdIns(3)P effectors double-FYVE containing protein 1 (DFCP1) and WD-repeat protein interacting with phosphoinositides 1 (WIPI-1), both of which function at the onset of autophagy. These data provide evidence for additional roles of Atg2A and Atg14L in the formation of early autophagosomal membranes and also in lipid metabolism.</dcterms:abstract> <dc:creator>Cezanne, Alice</dc:creator> <dc:contributor>Tschan, Mario P.</dc:contributor> <dcterms:title>Lipid droplet and early autophagosomal membrane targeting of Atg2A and Atg14L in human tumor cells</dcterms:title> <dc:contributor>Cezanne, Alice</dc:contributor> <dc:contributor>Proikas-Cezanne, Tassula</dc:contributor> <dc:creator>Bakula, Daniela</dc:creator> <dc:creator>Pfisterer, Simon G.</dc:creator> <dc:contributor>Pfisterer, Simon G.</dc:contributor> </rdf:Description> </rdf:RDF>

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