KOPS - Das Institutionelle Repositorium der Universität Konstanz

Recalcitrant pharmaceuticals in the aquatic environment : a comparative screening study of their occurrence, formation of phototransformation products and their in vitro toxicity

Recalcitrant pharmaceuticals in the aquatic environment : a comparative screening study of their occurrence, formation of phototransformation products and their in vitro toxicity

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:72c1ed2d9d0ccb5ee7a36968d1f2eda4

BERGHEIM, Marlies, Richard GMINSKI, Bernd SPANGENBERG, Malgorzata DEBIAK, Alexander BÜRKLE, Volker MERSCH-SUNDERMANN, Klaus KÜMMERER, Reto GIERÉ, 2014. Recalcitrant pharmaceuticals in the aquatic environment : a comparative screening study of their occurrence, formation of phototransformation products and their in vitro toxicity. In: Environmental Chemistry. 11(4), pp. 431-444. ISSN 1448-2517. eISSN 1449-8979. Available under: doi: 10.1071/EN13218

@article{Bergheim2014Recal-29559, title={Recalcitrant pharmaceuticals in the aquatic environment : a comparative screening study of their occurrence, formation of phototransformation products and their in vitro toxicity}, year={2014}, doi={10.1071/EN13218}, number={4}, volume={11}, issn={1448-2517}, journal={Environmental Chemistry}, pages={431--444}, author={Bergheim, Marlies and Gminski, Richard and Spangenberg, Bernd and Debiak, Malgorzata and Bürkle, Alexander and Mersch-Sundermann, Volker and Kümmerer, Klaus and Gieré, Reto} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/29559"> <dc:creator>Mersch-Sundermann, Volker</dc:creator> <dc:contributor>Kümmerer, Klaus</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/29559"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:abstract xml:lang="eng">Data allowing for a complete environmental risk assessment of pharmaceuticals and their photoderatives in the environment are still scarce. In the present study, in vitro toxicity and both bio- and photopersistence of various pharmaceuticals (aciclovir, allopurinol, cetirizine, cimetidine, fluconazole, hydrochlorothiazide, lisinopril, phenytoin, primidone, ranitidine, sotalol, sulpiride, tramadol and valsartane) as well as their phototransformation products were evaluated in order to fill data gaps and to help prioritise them for further testing. Twelve out of the fourteen compounds investigated were found to be neither readily nor inherently biodegradable in the Organisation of Economic Cooperation and Development-biodegradability tests. The study further demonstrates that the photo-induced transformation of the pharmaceuticals was faster upon irradiation with a Hg lamp (UV light) than with a Xe lamp emitting a spectrum that mimics sunlight. Comparing the non-irradiated with the respective irradiated solutions, a higher acute and chronic toxicity against bacteria was found for the irradiated solutions of seven compounds (cetirizine, cimetidine, hydrochlorothiazide, ranitidine, sulpiride, tramadol and valsartane). No cyto- and genotoxic effects were found in human cervical (HeLa) and liver (Hep-G2) cells for any of the investigated compounds or their phototransformation products. This comparative study documents that phototransformation products can arise as a result of UV treatment of wastewater containing these pharmaceuticals. It further demonstrates that some phototransformation products may have a higher environmental risk potential than the respective parent compounds because some phototransformation products exhibited a higher bacterial toxicity.</dcterms:abstract> <dc:contributor>Gieré, Reto</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/29559/1/Bergheim_0-265718.pdf"/> <dc:contributor>Bürkle, Alexander</dc:contributor> <dc:contributor>Bergheim, Marlies</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Gminski, Richard</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-01-21T08:12:52Z</dc:date> <dc:contributor>Spangenberg, Bernd</dc:contributor> <dcterms:title>Recalcitrant pharmaceuticals in the aquatic environment : a comparative screening study of their occurrence, formation of phototransformation products and their in vitro toxicity</dcterms:title> <dc:creator>Kümmerer, Klaus</dc:creator> <dc:creator>Bergheim, Marlies</dc:creator> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/29559/1/Bergheim_0-265718.pdf"/> <dc:creator>Gminski, Richard</dc:creator> <dc:language>eng</dc:language> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dc:creator>Spangenberg, Bernd</dc:creator> <dc:contributor>Mersch-Sundermann, Volker</dc:contributor> <dcterms:issued>2014</dcterms:issued> <dc:creator>Bürkle, Alexander</dc:creator> <dc:creator>Debiak, Malgorzata</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-01-21T08:12:52Z</dcterms:available> <dc:contributor>Debiak, Malgorzata</dc:contributor> <dc:creator>Gieré, Reto</dc:creator> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 21.01.2015 (Informationen über die Zugriffsstatistik)

Bergheim_0-265718.pdf 349

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto