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Modulation of alertness by sustained cognitive demand in MS as surrogate measure of fatigue and fatigability

Modulation of alertness by sustained cognitive demand in MS as surrogate measure of fatigue and fatigability

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NEUMANN, Micha, Annette STERR, Dolores CLAROS-SALINAS, Rolf GÜTLER, Rolf ULRICH, Christian DETTMERS, 2014. Modulation of alertness by sustained cognitive demand in MS as surrogate measure of fatigue and fatigability. In: Journal of the Neurological Sciences. 340(1-2), pp. 178-182. ISSN 0022-510X. eISSN 1878-5883. Available under: doi: 10.1016/j.jns.2014.03.024

@article{Neumann2014Modul-29514, title={Modulation of alertness by sustained cognitive demand in MS as surrogate measure of fatigue and fatigability}, year={2014}, doi={10.1016/j.jns.2014.03.024}, number={1-2}, volume={340}, issn={0022-510X}, journal={Journal of the Neurological Sciences}, pages={178--182}, author={Neumann, Micha and Sterr, Annette and Claros-Salinas, Dolores and Gütler, Rolf and Ulrich, Rolf and Dettmers, Christian} }

Gütler, Rolf Sterr, Annette Neumann, Micha Dettmers, Christian 2014 Claros-Salinas, Dolores Objective<br />This study used reaction time (RT) as an objective marker of cognitive fatigue and fatigability in patients with multiple sclerosis (MS).<br /><br />Method<br />RT was measured in fifteen healthy controls and in thirty MS patients with cognitive fatigue identified with the Fatigue Scale for Motor and Cognitive Function (FSMC). Secondary fatigue was excluded through the Epworth Sleepiness Scale and the Beck Depression Inventory. RT was measured at rest (t1), following a 2.5 hour test session inducing high cognitive load (t2), and a one hour recovery period (t3).<br /><br />Results<br />At rest mean RT was longer in patients than in controls (391 ms vs 205 ms). After exerting cognitive load (t2), RT in patients increased dramatically but remained unchanged in controls. After the recovery period (t3), RT returned to baseline levels in most patients. Patients further showed a significant correlation between RT and FMSC scores at t1, t2 and t3.<br /><br />Conclusion<br />RT performance is a suitable surrogate marker for assessing fatigue. RT is sensitive to cognitive load and the recovery from cognitive demand. It hence represents an objective index for fatigability which can inform the management and treatment of MS. eng Ulrich, Rolf Modulation of alertness by sustained cognitive demand in MS as surrogate measure of fatigue and fatigability Claros-Salinas, Dolores Sterr, Annette 2015-01-15T15:37:08Z Gütler, Rolf Dettmers, Christian Neumann, Micha Ulrich, Rolf 2015-01-15T15:37:08Z

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