The genomic substrate for adaptive radiation in African cichlid fish

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:6de73bcc6a923d86896e053fcb6b9ba3

STREEKMAN, J. Todd, Kerstin LINDBLAD-TOH, Ole SEEHAUSEN, Federica DI PALMA, Shaohua FAN, Oleg SIMAKOV, Axel MEYER, 2014. The genomic substrate for adaptive radiation in African cichlid fish. In: Nature. 513(7518), pp. 375-381. ISSN 0028-0836. eISSN 1476-4687. Available under: doi: 10.1038/nature13726

@article{Streekman2014genom-29323, title={The genomic substrate for adaptive radiation in African cichlid fish}, year={2014}, doi={10.1038/nature13726}, number={7518}, volume={513}, issn={0028-0836}, journal={Nature}, pages={375--381}, author={Streekman, J. Todd and Lindblad-Toh, Kerstin and Seehausen, Ole and Di Palma, Federica and Fan, Shaohua and Simakov, Oleg and Meyer, Axel} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/29323"> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-11-27T09:30:15Z</dcterms:available> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/29323/1/Brawand_0-258784.pdf"/> <dcterms:issued>2014</dcterms:issued> <dc:contributor>Seehausen, Ole</dc:contributor> <dc:creator>Seehausen, Ole</dc:creator> <dc:creator>Simakov, Oleg</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/29323"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/29323/1/Brawand_0-258784.pdf"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-11-27T09:30:15Z</dc:date> <dc:contributor>Lindblad-Toh, Kerstin</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Streekman, J. Todd</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Simakov, Oleg</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Meyer, Axel</dc:creator> <dc:contributor>Di Palma, Federica</dc:contributor> <dc:contributor>Fan, Shaohua</dc:contributor> <dc:creator>Fan, Shaohua</dc:creator> <dc:creator>Lindblad-Toh, Kerstin</dc:creator> <dc:contributor>Meyer, Axel</dc:contributor> <dcterms:title>The genomic substrate for adaptive radiation in African cichlid fish</dcterms:title> <dcterms:abstract xml:lang="eng">Cichlid fishes are famous for large, diverse and replicated adaptive radiations in the Great Lakes of East Africa. To understand the molecular mechanisms underlying cichlid phenotypic diversity, we sequenced the genomes and transcriptomes of five lineages of African cichlids: the Nile tilapia (Oreochromis niloticus), an ancestral lineage with low diversity; and four members of the East African lineage: Neolamprologus brichardi/pulcher (older radiation, Lake Tanganyika), Metriaclima zebra (recent radiation, Lake Malawi), Pundamilia nyererei (very recent radiation, Lake Victoria), and Astatotilapia burtoni (riverine species around Lake Tanganyika). We found an excess of gene duplications in the East African lineage compared to tilapia and other teleosts, an abundance of non-coding element divergence, accelerated coding sequence evolution, expression divergence associated with transposable element insertions, and regulation by novel microRNAs. In addition, we analysed sequence data from sixty individuals representing six closely related species from Lake Victoria, and show genome-wide diversifying selection on coding and regulatory variants, some of which were recruited from ancient polymorphisms. We conclude that a number of molecular mechanisms shaped East African cichlid genomes, and that amassing of standing variation during periods of relaxed purifying selection may have been important in facilitating subsequent evolutionary diversification.</dcterms:abstract> <dc:creator>Di Palma, Federica</dc:creator> <dc:contributor>Streekman, J. Todd</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.de/urn:nbn:de:bsz:352-20150914100631302-4485392-8"/> <dc:language>eng</dc:language> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 27.11.2014 (Informationen über die Zugriffsstatistik)

Brawand_0-258784.pdf 91

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto