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Impact of changed positive and negative task-related brain activity on word-retrieval in aging

Impact of changed positive and negative task-related brain activity on word-retrieval in aging

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Prüfsumme: MD5:b85558d3ea79a532e6d10323a0b5c4f0

MEINZER, Marcus, Lauren SEEDS, Tobias FLAISCH, Stacy HARNISH, Matt L. COHEN, Keith MCGREGOR, Tim CONWAY, Michelle BENJAMIN, Bruce CROSSON, 2012. Impact of changed positive and negative task-related brain activity on word-retrieval in aging. In: Neurobiology of Aging. 33(4), pp. 656-669. ISSN 0197-4580. eISSN 1558-1497. Available under: doi: 10.1016/j.neurobiolaging.2010.06.020

@article{Meinzer2012-04Impac-29027, title={Impact of changed positive and negative task-related brain activity on word-retrieval in aging}, year={2012}, doi={10.1016/j.neurobiolaging.2010.06.020}, number={4}, volume={33}, issn={0197-4580}, journal={Neurobiology of Aging}, pages={656--669}, author={Meinzer, Marcus and Seeds, Lauren and Flaisch, Tobias and Harnish, Stacy and Cohen, Matt L. and McGregor, Keith and Conway, Tim and Benjamin, Michelle and Crosson, Bruce} }

Previous functional imaging studies that compared activity patterns in older and younger adults during nonlinguistic tasks found evidence for 2 phenomena: older participants usually show more pronounced task-related positive activity in the brain hemisphere that is not dominant for the task and less pronounced negative task-related activity in temporo-parietal and midline brain regions. The combined effects of these phenomena and the impact on word retrieval, however, have not yet been assessed. We used functional magnetic resonance imaging to explore task-related positive (active task > baseline) and negative activity (baseline > active task) during semantic and phonemic verbal fluency tasks. Increased right frontal positive activity during the semantic task and reduced negative activity in the right hemisphere during both tasks was associated with reduced performance in older subjects. No substantial relationship between changes in positive and negative activity was observed in the older participants, pointing toward 2 partially independent but potentially co-occurring processes. Underlying causes of the observed functional network inefficiency during word retrieval in older adults need to be determined in the future. Impact of changed positive and negative task-related brain activity on word-retrieval in aging Meinzer, Marcus Harnish, Stacy Crosson, Bruce McGregor, Keith Benjamin, Michelle 2014-09-29T15:50:57Z 2012-04 eng Seeds, Lauren Crosson, Bruce Cohen, Matt L. Harnish, Stacy Conway, Tim Seeds, Lauren Benjamin, Michelle 2014-09-29T15:50:57Z Cohen, Matt L. Conway, Tim McGregor, Keith Meinzer, Marcus deposit-license Flaisch, Tobias Flaisch, Tobias Neurobiology of aging ; 33 (2012), 4. - S. 656-669

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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