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The effect of trauma-focused therapy on the altered T cell distribution in individuals with PTSD : evidence from a randomized controlled trial

The effect of trauma-focused therapy on the altered T cell distribution in individuals with PTSD : evidence from a randomized controlled trial

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Prüfsumme: MD5:50604d239acd3e18dc6fb241b4982150

MORATH, Julia, Hannah GOLA, Annette SOMMERSHOF, Gilava HAMUNI, Stephan KOLASSA, Claudia CATANI, Hannah ADENAUER, Martina RUF-LEUSCHNER, Maggie SCHAUER, Thomas ELBERT, Marcus GROETTRUP, Iris-Tatjana KOLASSA, 2014. The effect of trauma-focused therapy on the altered T cell distribution in individuals with PTSD : evidence from a randomized controlled trial. In: Journal of Psychiatric Research. 54, pp. 1-10. ISSN 0022-3956. eISSN 1879-1379

@article{Morath2014-07effec-28951, title={The effect of trauma-focused therapy on the altered T cell distribution in individuals with PTSD : evidence from a randomized controlled trial}, year={2014}, doi={10.1016/j.jpsychires.2014.03.016}, volume={54}, issn={0022-3956}, journal={Journal of Psychiatric Research}, pages={1--10}, author={Morath, Julia and Gola, Hannah and Sommershof, Annette and Hamuni, Gilava and Kolassa, Stephan and Catani, Claudia and Adenauer, Hannah and Ruf-Leuschner, Martina and Schauer, Maggie and Elbert, Thomas and Groettrup, Marcus and Kolassa, Iris-Tatjana} }

deposit-license Adenauer, Hannah Catani, Claudia Gola, Hannah Ruf-Leuschner, Martina Kolassa, Iris-Tatjana Ruf-Leuschner, Martina 2014-07 eng Catani, Claudia Hamuni, Gilava 2014-09-18T13:22:06Z Adenauer, Hannah Kolassa, Stephan Kolassa, Iris-Tatjana Gola, Hannah Elbert, Thomas 2014-09-18T13:22:06Z Groettrup, Marcus Elbert, Thomas Posttraumatic stress disorder (PTSD) is associated with a reduced ratio of naïve cytotoxic T lymphocytes, an increased ratio of memory cytotoxic T lymphocytes, and a reduced proportion of FoxP3+ regulatory T lymphocytes. This study investigated whether these immunological alterations are reversible through an evidence-based psychotherapeutic treatment. Therefore, 34 individuals with PTSD were randomly assigned to either a treatment condition of 12 sessions narrative exposure therapy (NET) or a waitlist control (WLC) group. PTSD symptoms were significantly reduced in the NET group, but not in the WLC group, four months post-therapy (effect size: Hedges' g = −1.61). One year after therapy, PTSD symptoms were improved even further in the NET group compared to baseline (Hedges' g = −1.96). This symptom improvement was mirrored in an increase in the originally reduced proportion of regulatory T cells (T<sub>regs</sub>) in the NET group at the one-year follow-up, when comparing subgroups matched for baseline T<sub>reg</sub> numbers. However, no changes were found for the initially reduced proportion of CD45RA+CCR7+ naïve T lymphocytes. In conclusion, NET was effective in reducing trauma-related PTSD symptoms and had a positive effect on the proportion of T<sub>regs</sub> cells, thus demonstrating an effect of psychotherapy on an immunological level. Yet, the shift in the proportion of naïve and memory T lymphocytes in individuals with PTSD, discussed in the literature as a correlate of premature immunosenescence, was not reversible and thus might render these patients permanently more susceptible to infectious diseases. Schauer, Maggie Groettrup, Marcus Sommershof, Annette Schauer, Maggie Journal of psychiatric research ; 54 (2014). - S. 1-10 Kolassa, Stephan Hamuni, Gilava Morath, Julia The effect of trauma-focused therapy on the altered T cell distribution in individuals with PTSD : evidence from a randomized controlled trial Morath, Julia Sommershof, Annette

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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