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The effect of trauma-focused therapy on the altered T cell distribution in individuals with PTSD : evidence from a randomized controlled trial

The effect of trauma-focused therapy on the altered T cell distribution in individuals with PTSD : evidence from a randomized controlled trial

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Prüfsumme: MD5:50604d239acd3e18dc6fb241b4982150

MORATH, Julia, Hannah GOLA, Annette SOMMERSHOF, Gilava HAMUNI, Stephan KOLASSA, Claudia CATANI, Hannah ADENAUER, Martina RUF-LEUSCHNER, Maggie SCHAUER, Thomas ELBERT, Marcus GROETTRUP, Iris-Tatjana KOLASSA, 2014. The effect of trauma-focused therapy on the altered T cell distribution in individuals with PTSD : evidence from a randomized controlled trial. In: Journal of Psychiatric Research. 54, pp. 1-10. ISSN 0022-3956. eISSN 1879-1379. Available under: doi: 10.1016/j.jpsychires.2014.03.016

@article{Morath2014-07effec-28951, title={The effect of trauma-focused therapy on the altered T cell distribution in individuals with PTSD : evidence from a randomized controlled trial}, year={2014}, doi={10.1016/j.jpsychires.2014.03.016}, volume={54}, issn={0022-3956}, journal={Journal of Psychiatric Research}, pages={1--10}, author={Morath, Julia and Gola, Hannah and Sommershof, Annette and Hamuni, Gilava and Kolassa, Stephan and Catani, Claudia and Adenauer, Hannah and Ruf-Leuschner, Martina and Schauer, Maggie and Elbert, Thomas and Groettrup, Marcus and Kolassa, Iris-Tatjana} }

Kolassa, Stephan Elbert, Thomas The effect of trauma-focused therapy on the altered T cell distribution in individuals with PTSD : evidence from a randomized controlled trial Ruf-Leuschner, Martina Hamuni, Gilava Catani, Claudia Sommershof, Annette Journal of psychiatric research ; 54 (2014). - S. 1-10 Adenauer, Hannah 2014-09-18T13:22:06Z Elbert, Thomas Adenauer, Hannah Schauer, Maggie Hamuni, Gilava 2014-07 eng deposit-license Ruf-Leuschner, Martina Gola, Hannah Groettrup, Marcus Posttraumatic stress disorder (PTSD) is associated with a reduced ratio of naïve cytotoxic T lymphocytes, an increased ratio of memory cytotoxic T lymphocytes, and a reduced proportion of FoxP3+ regulatory T lymphocytes. This study investigated whether these immunological alterations are reversible through an evidence-based psychotherapeutic treatment. Therefore, 34 individuals with PTSD were randomly assigned to either a treatment condition of 12 sessions narrative exposure therapy (NET) or a waitlist control (WLC) group. PTSD symptoms were significantly reduced in the NET group, but not in the WLC group, four months post-therapy (effect size: Hedges' g = −1.61). One year after therapy, PTSD symptoms were improved even further in the NET group compared to baseline (Hedges' g = −1.96). This symptom improvement was mirrored in an increase in the originally reduced proportion of regulatory T cells (T<sub>regs</sub>) in the NET group at the one-year follow-up, when comparing subgroups matched for baseline T<sub>reg</sub> numbers. However, no changes were found for the initially reduced proportion of CD45RA+CCR7+ naïve T lymphocytes. In conclusion, NET was effective in reducing trauma-related PTSD symptoms and had a positive effect on the proportion of T<sub>regs</sub> cells, thus demonstrating an effect of psychotherapy on an immunological level. Yet, the shift in the proportion of naïve and memory T lymphocytes in individuals with PTSD, discussed in the literature as a correlate of premature immunosenescence, was not reversible and thus might render these patients permanently more susceptible to infectious diseases. Kolassa, Iris-Tatjana Morath, Julia Kolassa, Stephan Catani, Claudia Kolassa, Iris-Tatjana Sommershof, Annette Gola, Hannah 2014-09-18T13:22:06Z Groettrup, Marcus Morath, Julia Schauer, Maggie

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