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A Pair of Inhibitory Neurons Are Required to Sustain Labile Memory in the Drosophila Mushroom Body

A Pair of Inhibitory Neurons Are Required to Sustain Labile Memory in the Drosophila Mushroom Body

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PITMAN, Jena L., Wolf HUETTEROTH, Christopher J. BURKE, Michael J. KRASHES, Sen-Lin LAI, Tzumin LEE, Scott WADDELL, 2011. A Pair of Inhibitory Neurons Are Required to Sustain Labile Memory in the Drosophila Mushroom Body. In: Current Biology. 21(10), pp. 855-861. ISSN 0960-9822. eISSN 1879-0445. Available under: doi: 10.1016/j.cub.2011.03.069

@article{Pitman2011-05-24Inhib-28907, title={A Pair of Inhibitory Neurons Are Required to Sustain Labile Memory in the Drosophila Mushroom Body}, year={2011}, doi={10.1016/j.cub.2011.03.069}, number={10}, volume={21}, issn={0960-9822}, journal={Current Biology}, pages={855--861}, author={Pitman, Jena L. and Huetteroth, Wolf and Burke, Christopher J. and Krashes, Michael J. and Lai, Sen-Lin and Lee, Tzumin and Waddell, Scott} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/28907"> <dc:creator>Waddell, Scott</dc:creator> <dcterms:bibliographicCitation>Current biology ; 21 (2011), 10. - S. 855-861</dcterms:bibliographicCitation> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:language>eng</dc:language> <dc:creator>Lee, Tzumin</dc:creator> <dc:creator>Burke, Christopher J.</dc:creator> <dcterms:title>A Pair of Inhibitory Neurons Are Required to Sustain Labile Memory in the Drosophila Mushroom Body</dcterms:title> <dcterms:issued>2011-05-24</dcterms:issued> <dc:contributor>Lai, Sen-Lin</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Pitman, Jena L.</dc:contributor> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/28907/2/Pitman_289077.pdf"/> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dcterms:abstract xml:lang="eng">Labile memory is thought to be held in the brain as persistent neural network activity. However, it is not known how biologically relevant memory circuits are organized and operate. Labile and persistent appetitive memory in Drosophila requires output after training from the α′β′ subset of mushroom body (MB) neurons and from a pair of modulatory dorsal paired medial (DPM) neurons. DPM neurons innervate the entire MB lobe region and appear to be pre- and postsynaptic to the MB, consistent with a recurrent network model. Here we identify a role after training for synaptic output from the GABAergic anterior paired lateral (APL) neurons. Blocking synaptic output from APL neurons after training disrupts labile memory but does not affect long-term memory. APL neurons contact DPM neurons most densely in the α′β′ lobes, although their processes are intertwined and contact throughout all of the lobes. Furthermore, APL contacts MB neurons in the α′ lobe but makes little direct contact with those in the distal α lobe. We propose that APL neurons provide widespread inhibition to stabilize and maintain synaptic specificity of a labile memory trace in a recurrent DPM and MB α′β′ neuron circuit.</dcterms:abstract> <dc:contributor>Krashes, Michael J.</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/28907"/> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/28907/2/Pitman_289077.pdf"/> <dc:creator>Krashes, Michael J.</dc:creator> <dc:contributor>Huetteroth, Wolf</dc:contributor> <dc:creator>Lai, Sen-Lin</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-09-05T14:03:34Z</dc:date> <dc:creator>Pitman, Jena L.</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-09-05T14:03:34Z</dcterms:available> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Lee, Tzumin</dc:contributor> <dc:rights>deposit-license</dc:rights> <dc:creator>Huetteroth, Wolf</dc:creator> <dc:contributor>Burke, Christopher J.</dc:contributor> <dc:contributor>Waddell, Scott</dc:contributor> </rdf:Description> </rdf:RDF>

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