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Different Kenyon Cell Populations Drive Learned Approach and Avoidance in Drosophila

Different Kenyon Cell Populations Drive Learned Approach and Avoidance in Drosophila

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Prüfsumme: MD5:5703b2b9af4c2e73efadc8b6534e2721

PERISSE, Emmanuel, Yan YIN, Andrew C. LIN, Suewei LIN, Wolf HUETTEROTH, Scott WADDELL, 2013. Different Kenyon Cell Populations Drive Learned Approach and Avoidance in Drosophila. In: Neuron. 79(5), pp. 945-956. ISSN 0896-6273. eISSN 1097-4199

@article{Perisse2013-09-04Diffe-28900, title={Different Kenyon Cell Populations Drive Learned Approach and Avoidance in Drosophila}, year={2013}, doi={10.1016/j.neuron.2013.07.045}, number={5}, volume={79}, issn={0896-6273}, journal={Neuron}, pages={945--956}, author={Perisse, Emmanuel and Yin, Yan and Lin, Andrew C. and Lin, Suewei and Huetteroth, Wolf and Waddell, Scott} }

2014-09-05T11:24:46Z 2014-09-05T11:24:46Z Perisse, Emmanuel Lin, Suewei Waddell, Scott Huetteroth, Wolf Huetteroth, Wolf 2013-09-04 Different Kenyon Cell Populations Drive Learned Approach and Avoidance in Drosophila eng Lin, Suewei Lin, Andrew C. In Drosophila, anatomically discrete dopamine neurons that innervate distinct zones of the mushroom body (MB) assign opposing valence to odors during olfactory learning. Subsets of MB neurons have temporally unique roles in memory processing, but valence-related organization has not been demonstrated. We functionally subdivided the αβ neurons, revealing a value-specific role for the ∼160 αβ core (αβ<sub>c</sub>) neurons. Blocking neurotransmission from αβ surface (αβ<sub>s</sub>) neurons revealed a requirement during retrieval of aversive and appetitive memory, whereas blocking αβ<sub>c</sub> only impaired appetitive memory. The αβc were also required to express memory in a differential aversive paradigm demonstrating a role in relative valuation and approach behavior. Strikingly, both reinforcing dopamine neurons and efferent pathways differentially innervate αβ<sub>c</sub> and αβs in the MB lobes. We propose that conditioned approach requires pooling synaptic outputs from across the αβ ensemble but only from the αβs for conditioned aversion. Neuron ; 79 (2013), 5. - S. 945-956 Yin, Yan Perisse, Emmanuel deposit-license Yin, Yan Lin, Andrew C. Waddell, Scott

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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