Oligonucleotide-modified Nuclotides

Type of Publication: Dissertation
URI (citable link): http://nbn-resolving.de/urn:nbn:de:bsz:352-288756
Author: Steck, Anna-Lena
Year of publication: 2013
Summary:
Modified nucleotides are interesting tools: They can alter the characteristics of DNA in many ways and enable the applicability of DNA in several innovative biotechnological applications.

The first part of this thesis contributes to a better understanding of the acceptance and incorporation mechanism of modified nucleotides by DNA polymerases. Therefore modified nucleotides were successfully synthesized and incorporated into DNA by diverse DNA polymerases.
Summary in another language:
Modifizierte Nukleotide stellen ein vielseitiges Ausgangsmaterial dar: Sie können die Eigenschaften von DNA beeinflussen oder verändern und ermöglichen somit die Verwendung von DNA in zahlreichen innovativen biotechnischen Anwendungen.

Der erste Teil dieser Arbeit trägt zu einem besseren Verständnis des Akzeptanzmechanismus und des Einbaumechanismus von modifizierten Nukleotiden durch DNA Polymerasen bei. Hierfür wurden modifizierte Nukleotide synthetisiert und mittels verschiedener DNA-Polymerasen in DNA eingebaut.
Examination date (for dissertations): Dec 13, 2013
Dissertation note: Doctoral dissertation, University of Konstanz
Subject (DDC): 540 Chemistry
Link to License: Terms of use

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STECK, Anna-Lena, 2013. Oligonucleotide-modified Nuclotides [Dissertation]. Konstanz: University of Konstanz

@phdthesis{Steck2013Oligo-28875, title={Oligonucleotide-modified Nuclotides}, year={2013}, author={Steck, Anna-Lena}, address={Konstanz}, school={Universität Konstanz} }

2014-09-01T09:27:05Z 2014-09-01T09:27:05Z Steck, Anna-Lena Steck, Anna-Lena terms-of-use 2013 Oligonucleotide-modified Nuclotides eng Modified nucleotides are interesting tools: They can alter the characteristics of DNA in many ways and enable the applicability of DNA in several innovative biotechnological applications.<br /><br />The first part of this thesis contributes to a better understanding of the acceptance and incorporation mechanism of modified nucleotides by DNA polymerases. Therefore modified nucleotides were successfully synthesized and incorporated into DNA by diverse DNA polymerases.

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