Selective Monitoring of the Enzymatic Activity of the Tumor Suppressor Fhit

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HACKER, Stephan, Franziska MORTENSEN, Martin SCHEFFNER, Andreas MARX, 2014. Selective Monitoring of the Enzymatic Activity of the Tumor Suppressor Fhit. In: Angewandte Chemie International Edition. 53(38), pp. 10247-10250. ISSN 1433-7851. eISSN 1521-3773

@article{Hacker2014-09-15Selec-28857, title={Selective Monitoring of the Enzymatic Activity of the Tumor Suppressor Fhit}, year={2014}, doi={10.1002/anie.201405259}, number={38}, volume={53}, issn={1433-7851}, journal={Angewandte Chemie International Edition}, pages={10247--10250}, author={Hacker, Stephan and Mortensen, Franziska and Scheffner, Martin and Marx, Andreas} }

deposit-license 2014-09-15 2014-09-17T06:50:20Z Mortensen, Franziska Hacker, Stephan 2014-09-17T06:50:20Z eng Scheffner, Martin Marx, Andreas Hacker, Stephan Marx, Andreas Mortensen, Franziska Angewandte Chemie International Edition ; 53 (2014), 38. - S. 10247–10250 Selective Monitoring of the Enzymatic Activity of the Tumor Suppressor Fhit Scheffner, Martin Cancer is a leading cause of death worldwide. Functional inactivation of tumor suppressor proteins, mainly by mutations in the corresponding genes, is a key event in cancer development. The fragile histidine triade protein (Fhit) is a tumor suppressor that is frequently affected in different cancer types. Fhit possesses diadenosine triphosphate hydrolase activity, but although reduction of its enzymatic activity appears to be important for exerting its tumor suppressor function, the regulation of Fhit activity is poorly understood. Here, we introduce a novel fluorogenic probe that is suited to selectively analyze the enzymatic activity of Fhit in extracts derived from human cells. This novel method will allow indepth insight into the mechanisms involved in Fhit regulation in biologically relevant setups and, thus, into its role in the<br />development of cancer.

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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