Synthesis and Activity of Biomimetic Biofilm Disruptors

Zitieren

Dateien zu dieser Ressource

Dateien Größe Format Anzeige

Zu diesem Dokument gibt es keine Dateien.

BÖTTCHER, Thomas, Ilana KOLODKIN-GAL, Roberto KOLTER, Richard LOSICK, Jon CLARDY, 2013. Synthesis and Activity of Biomimetic Biofilm Disruptors. In: Journal of the American Chemical Society. 135(8), pp. 2927-2930. ISSN 0002-7863. eISSN 1520-5126

@article{Bottcher2013-02-27Synth-28432, title={Synthesis and Activity of Biomimetic Biofilm Disruptors}, year={2013}, doi={10.1021/ja3120955}, number={8}, volume={135}, issn={0002-7863}, journal={Journal of the American Chemical Society}, pages={2927--2930}, author={Böttcher, Thomas and Kolodkin-Gal, Ilana and Kolter, Roberto and Losick, Richard and Clardy, Jon} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/28432"> <dc:contributor>Böttcher, Thomas</dc:contributor> <dc:creator>Losick, Richard</dc:creator> <dc:contributor>Losick, Richard</dc:contributor> <dc:contributor>Clardy, Jon</dc:contributor> <dc:language>eng</dc:language> <dc:creator>Kolter, Roberto</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/28432"/> <dc:contributor>Kolter, Roberto</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-07-22T07:06:22Z</dcterms:available> <dcterms:title>Synthesis and Activity of Biomimetic Biofilm Disruptors</dcterms:title> <dc:rights>deposit-license</dc:rights> <dcterms:bibliographicCitation>Journal of the American Chemical Society : JACS ; 135 (2013), 8. - S. 2927-2930</dcterms:bibliographicCitation> <dc:contributor>Kolodkin-Gal, Ilana</dc:contributor> <dc:creator>Clardy, Jon</dc:creator> <dcterms:issued>2013-02-27</dcterms:issued> <dcterms:abstract xml:lang="eng">Biofilms are often associated with human bacterial infections, and the natural tolerance of biofilms to antibiotics challenges treatment. Compounds with antibiofilm activity could become useful adjuncts to antibiotic therapy. We used norspermidine, a natural trigger for biofilm disassembly in the developmental cycle of Bacillus subtilis, to develop guanidine and biguanide compounds with up to 20-fold increased potency in preventing biofilm formation and breaking down existing biofilms. These compounds also were active against pathogenic Staphylococcus aureus. An integrated approach involving structure–activity relationships, protonation constants, and crystal structure data on a focused synthetic library revealed that precise spacing of positively charged groups and the total charge at physiological pH distinguish potent biofilm inhibitors.</dcterms:abstract> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-07-22T07:06:22Z</dc:date> <dc:creator>Böttcher, Thomas</dc:creator> <dc:creator>Kolodkin-Gal, Ilana</dc:creator> </rdf:Description> </rdf:RDF>

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto