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Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance

Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance

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MAYNARD, Scott, Guido KEIJZERS, Ase Marie HANSEN, Merete OSLER, Drude MOLBO, Laila BENDIX, Peter MØLLER, Steffen LOFT, Maria MORENO-VILLANUEVA, Alexander BÜRKLE, Christina Poulsen HVITBY, Shepherd H. SCHURMAN, Tinna STEVNSNER, Lene Juel RASMUSSEN, Kirsten AVLUND, Vilhelm A. BOHR, 2015. Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance. In: Acta Physiologica. 213(1), pp. 156-170. ISSN 1748-1708. eISSN 1748-1716

@article{Maynard2015-01Assoc-28419, title={Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance}, year={2015}, doi={10.1111/apha.12296}, number={1}, volume={213}, issn={1748-1708}, journal={Acta Physiologica}, pages={156--170}, author={Maynard, Scott and Keijzers, Guido and Hansen, Ase Marie and Osler, Merete and Molbo, Drude and Bendix, Laila and Møller, Peter and Loft, Steffen and Moreno-Villanueva, Maria and Bürkle, Alexander and Hvitby, Christina Poulsen and Schurman, Shepherd H. and Stevnsner, Tinna and Rasmussen, Lene Juel and Avlund, Kirsten and Bohr, Vilhelm A.} }

Bendix, Laila Moreno-Villanueva, Maria Møller, Peter 2014-07-16T07:32:36Z Keijzers, Guido Molbo, Drude Acta Physiologica Osler, Merete Molbo, Drude 2014-07-16T07:32:36Z Bohr, Vilhelm A. Aim: To examine associations of DNA damage, cardiovascular risk factors and physical performance with vitality, in middle-aged men. We also sought to elucidate underlying factors of physical performance by comparing physical performance parameters to DNA damage parameters and cardiovascular risk factors.<br /><br />Methods: We studied 2487 participants from the Metropolit cohort of 11 532 men born in 1953 in the Copenhagen Metropolitan area. The vitality level was estimated using the SF-36 vitality scale. Cardiovascular risk factors were determined by body mass index (BMI), and haematological biochemistry tests obtained from non-fasting participants. DNA damage parameters were measured in peripheral blood mononuclear cells (PBMCs) from as many participants as possible from a representative subset of 207 participants.<br /><br />Results: Vitality was inversely associated with spontaneous DNA breaks (measured by comet assay) (P = 0.046) and BMI (P = 0.002), and positively associated with all of the physical performance parameters (all P < 0.001). Also, we found several associations between physical performance parameters and cardiovascular risk factors. In addition, the load of short telomeres was inversely associated with maximum jump force (P = 0.018), with lowered significance after exclusion of either arthritis sufferers (P = 0.035) or smokers (P = 0.031).<br /><br />Conclusion: Here, we show that self-reported vitality is associated with DNA breaks, BMI and objective (measured) physical performance in a cohort of middle-aged men. Several other associations in this study verify clinical observations in medical practice. In addition, the load of short telomeres may be linked to peak performance in certain musculoskeletal activities. Loft, Steffen Bendix, Laila Moreno-Villanueva, Maria Avlund, Kirsten Schurman, Shepherd H. Rasmussen, Lene Juel deposit-license Bürkle, Alexander Hvitby, Christina Poulsen Stevnsner, Tinna Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance eng Hvitby, Christina Poulsen Loft, Steffen Bohr, Vilhelm A. Bürkle, Alexander Hansen, Ase Marie Stevnsner, Tinna Keijzers, Guido Osler, Merete Maynard, Scott Maynard, Scott 2015-01 Rasmussen, Lene Juel Avlund, Kirsten Hansen, Ase Marie Møller, Peter Schurman, Shepherd H.

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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