The unique functions of tissue-specific proteasomes


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KNIEPERT, Andrea, Marcus GRÖTTRUP, 2014. The unique functions of tissue-specific proteasomes. In: Trends in Biochemical Sciences. 39(1), pp. 17-24. ISSN 0968-0004. eISSN 1362-4326

@article{Kniepert2014-01uniqu-28324, title={The unique functions of tissue-specific proteasomes}, year={2014}, doi={10.1016/j.tibs.2013.10.004}, number={1}, volume={39}, issn={0968-0004}, journal={Trends in Biochemical Sciences}, pages={17--24}, author={Kniepert, Andrea and Gröttrup, Marcus} }

<rdf:RDF xmlns:rdf="" xmlns:bibo="" xmlns:dc="" xmlns:dcterms="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dcterms:abstract xml:lang="eng">The 26S proteasome is the main protease in eukaryotes. Proteolysis occurs within the cylindrical 20S proteasome that is constitutively expressed in most tissues. However, three tissue-specific versions of the 20S proteasome have been discovered to date. The immunoproteasome is optimized to process antigens and it directs the differentiation of T helper (Th) cells. The thymoproteasome is selectively expressed in cortical epithelial cells of the thymus where it plays an essential role in the positive selection of T lymphocytes. Finally, the spermatoproteasome is found in the testes where it is required during spermatogenesis. Here, we outline how tissue-specific proteasomes adapt to functional needs in their respective tissues and how their selective inhibition may be used to interfere with autoimmune diseases and cancer.</dcterms:abstract> <dcterms:available rdf:datatype="">2014-07-09T15:14:08Z</dcterms:available> <dc:rights>deposit-license</dc:rights> <dcterms:rights rdf:resource=""/> <bibo:uri rdf:resource=""/> <dc:contributor>Kniepert, Andrea</dc:contributor> <dc:creator>Gröttrup, Marcus</dc:creator> <dcterms:issued>2014-01</dcterms:issued> <dcterms:bibliographicCitation>Trends in biochemical sciences ; 39 (2014), 1. - S. 17-24</dcterms:bibliographicCitation> <dc:language>eng</dc:language> <dcterms:title>The unique functions of tissue-specific proteasomes</dcterms:title> <dc:creator>Kniepert, Andrea</dc:creator> <dc:contributor>Gröttrup, Marcus</dc:contributor> <dc:date rdf:datatype="">2014-07-09T15:14:08Z</dc:date> </rdf:Description> </rdf:RDF>

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