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Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis

Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis

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BASLER, Michael, Sarah MUNDT, Tony MUCHAMUEL, Carlo MOLL, Jing JIANG, Marcus GRÖTTRUP, Christopher J. KIRK, 2014. Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis. In: EMBO Molecular Medicine. 6(2), pp. 226-38-238. ISSN 1757-4676. eISSN 1757-4684. Available under: doi: 10.1002/emmm.201303543

@article{Basler2014-02Inhib-28323, title={Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis}, year={2014}, doi={10.1002/emmm.201303543}, number={2}, volume={6}, issn={1757-4676}, journal={EMBO Molecular Medicine}, pages={226-38--238}, author={Basler, Michael and Mundt, Sarah and Muchamuel, Tony and Moll, Carlo and Jiang, Jing and Gröttrup, Marcus and Kirk, Christopher J.} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/28323"> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-07-09T14:25:55Z</dcterms:available> <dc:creator>Gröttrup, Marcus</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Jiang, Jing</dc:creator> <dc:contributor>Muchamuel, Tony</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-07-09T14:25:55Z</dc:date> <dcterms:bibliographicCitation>EMBO Molecular Medicine ; 6 (2014), 2. - S. 226-238</dcterms:bibliographicCitation> <dcterms:title>Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis</dcterms:title> <dc:contributor>Jiang, Jing</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/28323"/> <dc:language>eng</dc:language> <dc:rights>deposit-license</dc:rights> <dc:creator>Moll, Carlo</dc:creator> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/28323/2/Basler_283233.pdf"/> <dc:contributor>Mundt, Sarah</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Basler, Michael</dc:creator> <dc:contributor>Basler, Michael</dc:contributor> <dc:contributor>Gröttrup, Marcus</dc:contributor> <dc:contributor>Moll, Carlo</dc:contributor> <dc:contributor>Kirk, Christopher J.</dc:contributor> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/28323/2/Basler_283233.pdf"/> <dc:creator>Kirk, Christopher J.</dc:creator> <dc:creator>Muchamuel, Tony</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:creator>Mundt, Sarah</dc:creator> <dcterms:issued>2014-02</dcterms:issued> <dcterms:abstract xml:lang="eng">Multiple sclerosis (MS) is a chronic demyelinating immune mediated disease of the central nervous system. The immunoproteasome is a distinct class of proteasomes found predominantly in monocytes and lymphocytes. Recently, we demonstrated a novel function of immunoproteasomes in cytokine production and T cell differentiation. In this study, we investigated the therapeutic efficacy of an inhibitor of the immunoproteasome (ONX 0914) in two different mouse models of MS. ONX 0914 attenuated disease progression after active and passive induction of experimental autoimmune encephalomyelitis (EAE), both in MOG35–55 and PLP139–151-induced EAE. Isolation of lymphocytes from the brain or spinal cord revealed a strong reduction of cytokine-producing CD4+ cells in ONX 0914 treated mice. Additionally, ONX 0914 treatment prevented disease exacerbation in a relapsing-remitting model. An analysis of draining lymph nodes after induction of EAE revealed that the differentiation to Th17 or Th1 cells was strongly impaired in ONX 0914 treated mice. These results implicate the immunoproteasome in the development of EAE and suggest that immunoproteasome inhibitors are promising drugs for the treatment of MS.</dcterms:abstract> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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