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Reduced peripheral expression of the glucocorticoid receptor alpha isoform in individuals with posttraumatic stress disorder : a cumulative effect of trauma burden

Reduced peripheral expression of the glucocorticoid receptor alpha isoform in individuals with posttraumatic stress disorder : a cumulative effect of trauma burden

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GOLA, Hannah, Andrea ENGLER, Julia MORATH, Hannah ADENAUER, Thomas ELBERT, Iris-Tatjana KOLASSA, Harald ENGLER, 2014. Reduced peripheral expression of the glucocorticoid receptor alpha isoform in individuals with posttraumatic stress disorder : a cumulative effect of trauma burden. In: PLoS ONE. 9(1), e86333. eISSN 1932-6203

@article{Gola2014Reduc-28122, title={Reduced peripheral expression of the glucocorticoid receptor alpha isoform in individuals with posttraumatic stress disorder : a cumulative effect of trauma burden}, year={2014}, doi={10.1371/journal.pone.0086333}, number={1}, volume={9}, journal={PLoS ONE}, author={Gola, Hannah and Engler, Andrea and Morath, Julia and Adenauer, Hannah and Elbert, Thomas and Kolassa, Iris-Tatjana and Engler, Harald}, note={Article Number: e86333} }

Adenauer, Hannah 2014 Gola, Hannah 2014-06-16T11:47:25Z 2014-06-16T11:47:25Z Engler, Harald Reduced peripheral expression of the glucocorticoid receptor alpha isoform in individuals with posttraumatic stress disorder : a cumulative effect of trauma burden Engler, Andrea Engler, Harald Adenauer, Hannah Kolassa, Iris-Tatjana Background<br /><br />Posttraumatic stress disorder (PTSD) is a serious psychiatric condition that was found to be associated with altered functioning of the hypothalamic-pituitary-adrenal (HPA) axis and changes in glucocorticoid (GC) responsiveness. The physiological actions of GCs are primarily mediated through GC receptors (GR) of which isoforms with different biological activities exist. This study aimed to investigate whether trauma-experience and/or PTSD are associated with altered expression of GR splice variants.<br /><br /><br />Methods<br /><br />GRα and GRβ mRNA expression levels were determined by real-time quantitative PCR in whole blood samples of individuals with chronic and severe forms of PTSD (n = 42) as well as in ethnically matched reference subjects (non-PTSD, n = 35).<br /><br /><br />Results<br /><br />Individuals suffering from PTSD exhibited significantly lower expression of the predominant and functionally active GRα isoform compared to non-PTSD subjects. This effect remained significant when accounting for gender, smoking, psychotropic medication or comorbid depression. Moreover, the GRα expression level was significantly negatively correlated with the number of traumatic event types experienced, both in the whole sample and within the PTSD patient group. Expression of the less abundant and non-ligand binding GRβ isoform was comparable between patient and reference groups.<br /><br /><br />Conclusions<br /><br />Reduced expression of the functionally active GRα isoform in peripheral blood cells of individuals with PTSD seems to be a cumulative effect of trauma burden rather than a specific feature of PTSD since non-PTSD subjects with high trauma load showed an intermediate phenotype between PTSD patients and individuals with no or few traumatic experiences. PLoS ONE ; 9 (2014), 1. - e86333 Kolassa, Iris-Tatjana Morath, Julia eng Elbert, Thomas Elbert, Thomas deposit-license Gola, Hannah Morath, Julia Engler, Andrea

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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