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Effect of carotid endarterectomy or stenting on impairment of dynamic cerebral autoregulation

Effect of carotid endarterectomy or stenting on impairment of dynamic cerebral autoregulation

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REINHARD, Matthias, Markus ROTH, Thomas MÜLLER, Brigitte GUSCHLBAUER, Jens TIMMER, Marek CZOSNYKA, Andreas HETZEL, 2004. Effect of carotid endarterectomy or stenting on impairment of dynamic cerebral autoregulation. In: Stroke. 35(6), pp. 1381-1387. ISSN 0039-2499. eISSN 1524-4628. Available under: doi: 10.1161/01.STR.0000127533.46914.31

@article{Reinhard2004-06Effec-27134, title={Effect of carotid endarterectomy or stenting on impairment of dynamic cerebral autoregulation}, year={2004}, doi={10.1161/01.STR.0000127533.46914.31}, number={6}, volume={35}, issn={0039-2499}, journal={Stroke}, pages={1381--1387}, author={Reinhard, Matthias and Roth, Markus and Müller, Thomas and Guschlbauer, Brigitte and Timmer, Jens and Czosnyka, Marek and Hetzel, Andreas} }

Reinhard, Matthias Müller, Thomas Effect of carotid endarterectomy or stenting on impairment of dynamic cerebral autoregulation Timmer, Jens Stroke ; 35 (2004), 6. - S. 1381-1387 Czosnyka, Marek eng Roth, Markus Czosnyka, Marek 2014-04-07T08:03:32Z Hetzel, Andreas Timmer, Jens Müller, Thomas Guschlbauer, Brigitte Background and Purpose<br /><br />Analysis of dynamic cerebral autoregulation (DCA) from spontaneous blood pressure fluctuations might contribute to prognosis of severe internal carotid artery stenosis, but its response to carotid recanalization has not been investigated so far. This study investigates the effect of carotid endarterectomy or stenting on various DCA parameters.<br /><br /><br />Methods<br /><br />In 58 patients with severe unilateral stenosis undergoing carotid endarterectomy (n=41) or stenting (n=17), cerebral blood flow velocity (CBFV, transcranial Doppler) and arterial blood pressure (ABP, Finapres method) were recorded over 10 minutes before and on average 3 days after carotid recanalization. Nineteen patients were additionally examined after 7 months. Correlations between diastolic and mean ABP and CBFV fluctuations were averaged to form the correlation coefficient indices (diastolic [Dx] and mean values [Mx]). Transfer function parameters (low-frequency phase and high-frequency gain between ABP and CBFV oscillations) were calculated over the same 10 minutes. CO<sub>2</sub> reactivity was assessed via inhalation of 7\% CO<sub>2</sub>.<br /><br /><br />Results<br /><br />Before recanalization, all DCA parameters were clearly impaired ipsilaterally compared with contralateral sides. Phase, Dx, and Mx indicated early normalization of DCA after both endarterectomy and stenting. By multiple regression, the degree of DCA improvement was highly significantly related to the extent of impairment before recanalization. No significant change in DCA was found at follow-up. Ipsilateral gain and CO<sub>2</sub> reactivity increased significantly less after endarterectomy than after stenting (P<0.05).<br /><br /><br />Conclusions<br /><br />Dynamic cerebral dysautoregulation in patients with severe carotid obstruction is readily and completely remedied by carotid recanalization. Guschlbauer, Brigitte Hetzel, Andreas 2014-04-07T08:03:32Z 2004-06 Reinhard, Matthias Roth, Markus deposit-license

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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