KOPS - Das Institutionelle Repositorium der Universität Konstanz

Vascular aging : Chronic oxidative stress and impairment of redox signaling—consequences for vascular homeostasis and disease

Vascular aging : Chronic oxidative stress and impairment of redox signaling—consequences for vascular homeostasis and disease

Zitieren

Dateien zu dieser Ressource

Dateien Größe Format Anzeige

Zu diesem Dokument gibt es keine Dateien.

BACHSCHMID, Markus, Stefan SCHILDKNECHT, Reiko MATSUI, Rebecca ZEE, Dagmar HÄUSSLER, Richard COHEN, David PIMENTAL, Bernd VAN DER LOO, 2013. Vascular aging : Chronic oxidative stress and impairment of redox signaling—consequences for vascular homeostasis and disease. In: Annals of Medicine. 45(1), pp. 17-36. ISSN 0785-3890. eISSN 1365-2060

@article{Bachschmid2013-02Vascu-26683, title={Vascular aging : Chronic oxidative stress and impairment of redox signaling—consequences for vascular homeostasis and disease}, year={2013}, doi={10.3109/07853890.2011.645498}, number={1}, volume={45}, issn={0785-3890}, journal={Annals of Medicine}, pages={17--36}, author={Bachschmid, Markus and Schildknecht, Stefan and Matsui, Reiko and Zee, Rebecca and Häussler, Dagmar and Cohen, Richard and Pimental, David and van der Loo, Bernd} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/26683"> <dc:contributor>Zee, Rebecca</dc:contributor> <dc:contributor>Matsui, Reiko</dc:contributor> <dc:contributor>Cohen, Richard</dc:contributor> <dc:contributor>van der Loo, Bernd</dc:contributor> <dc:creator>Cohen, Richard</dc:creator> <dc:contributor>Schildknecht, Stefan</dc:contributor> <dcterms:bibliographicCitation>Annals of Medicine ; 45 (2013), 1. - S. 17-36</dcterms:bibliographicCitation> <dc:rights>deposit-license</dc:rights> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:contributor>Pimental, David</dc:contributor> <dc:creator>Schildknecht, Stefan</dc:creator> <dc:creator>Zee, Rebecca</dc:creator> <dc:contributor>Bachschmid, Markus</dc:contributor> <dcterms:issued>2013-02</dcterms:issued> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/26683"/> <dc:language>eng</dc:language> <dc:creator>Pimental, David</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-03-12T08:01:47Z</dc:date> <dc:creator>Häussler, Dagmar</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-03-12T08:01:47Z</dcterms:available> <dcterms:abstract xml:lang="eng">Characteristic morphological and molecular alterations such as vessel wall thickening and reduction of nitric oxide occur in the aging vasculature leading to the gradual loss of vascular homeostasis. Consequently, the risk of developing acute and chronic cardiovascular diseases increases with age. Current research of the underlying molecular mechanisms of endothelial function demonstrates a duality of reactive oxygen and nitrogen species in contributing to vascular homeostasis or leading to detrimental effects when formed in excess. Furthermore, changes in function and redox status of vascular smooth muscle cells contribute to age-related vascular remodeling. The age-dependent increase in free radical formation causes deterioration of the nitric oxide signaling cascade, alters and activates prostaglandin metabolism, and promotes novel oxidative posttranslational protein modifications that interfere with vascular and cell signaling pathways. As a result, vascular dysfunction manifests. Compensatory mechanisms are initially activated to cope with age-induced oxidative stress, but become futile, which results in irreversible oxidative modifications of biological macromolecules. These findings support the ‘free radical theory of aging’ but also show that reactive oxygen and nitrogen species are essential signaling molecules, regulating vascular homeostasis.</dcterms:abstract> <dc:creator>Bachschmid, Markus</dc:creator> <dc:creator>van der Loo, Bernd</dc:creator> <dcterms:title>Vascular aging : Chronic oxidative stress and impairment of redox signaling—consequences for vascular homeostasis and disease</dcterms:title> <dc:creator>Matsui, Reiko</dc:creator> <dc:contributor>Häussler, Dagmar</dc:contributor> </rdf:Description> </rdf:RDF>

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto