Interstitial dendritic cell guidance by haptotactic chemokine gradients

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:58a71f8bab3b3c91d9cb567bf3737c1a

WEBER, Michele, Robert HAUSCHILD, Jan SCHWARZ, Christine MOUSSION, Ingrid DE VRIES, Daniel LEGLER, Sanjiv A. LUTHER, Tobias BOLLENBACH, Michael SIXT, 2013. Interstitial dendritic cell guidance by haptotactic chemokine gradients. In: Science. 339(6117), pp. 328-332. ISSN 0036-8075. eISSN 1095-9203. Available under: doi: 10.1126/science.1228456

@article{Weber2013-01-18Inter-26341, title={Interstitial dendritic cell guidance by haptotactic chemokine gradients}, year={2013}, doi={10.1126/science.1228456}, number={6117}, volume={339}, issn={0036-8075}, journal={Science}, pages={328--332}, author={Weber, Michele and Hauschild, Robert and Schwarz, Jan and Moussion, Christine and de Vries, Ingrid and Legler, Daniel and Luther, Sanjiv A. and Bollenbach, Tobias and Sixt, Michael} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/26341"> <dc:contributor>Luther, Sanjiv A.</dc:contributor> <dc:contributor>Hauschild, Robert</dc:contributor> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/26341/2/Weber_263418.pdf"/> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/26341"/> <dc:creator>Schwarz, Jan</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-02-11T14:57:35Z</dc:date> <dc:creator>Legler, Daniel</dc:creator> <dc:contributor>Sixt, Michael</dc:contributor> <dcterms:title>Interstitial dendritic cell guidance by haptotactic chemokine gradients</dcterms:title> <dc:creator>de Vries, Ingrid</dc:creator> <dc:contributor>Bollenbach, Tobias</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Moussion, Christine</dc:contributor> <dcterms:issued>2013-01-18</dcterms:issued> <dc:creator>Weber, Michele</dc:creator> <dc:language>eng</dc:language> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/26341/2/Weber_263418.pdf"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:rights>deposit-license</dc:rights> <dc:contributor>de Vries, Ingrid</dc:contributor> <dc:creator>Luther, Sanjiv A.</dc:creator> <dc:contributor>Weber, Michele</dc:contributor> <dc:creator>Sixt, Michael</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:creator>Moussion, Christine</dc:creator> <dcterms:abstract xml:lang="eng">Directional guidance of cells via gradients of chemokines is considered crucial for embryonic development, cancer dissemination, and immune responses. Nevertheless, the concept still lacks direct experimental confirmation in vivo. Here, we identify endogenous gradients of the chemokine CCL21 within mouse skin and show that they guide dendritic cells toward lymphatic vessels. Quantitative imaging reveals depots of CCL21 within lymphatic endothelial cells and steeply decaying gradients within the perilymphatic interstitium. These gradients match the migratory patterns of the dendritic cells, which directionally approach vessels from a distance of up to 90-micrometers. Interstitial CCL21 is immobilized to heparan sulfates, and its experimental delocalization or swamping the endogenous gradients abolishes directed migration. These findings functionally establish the concept of haptotaxis, directed migration along immobilized gradients, in tissues.</dcterms:abstract> <dcterms:bibliographicCitation>Science ; 339 (2013), 6117. - S. 328-332</dcterms:bibliographicCitation> <dc:creator>Hauschild, Robert</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-02-11T14:57:35Z</dcterms:available> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Schwarz, Jan</dc:contributor> <dc:contributor>Legler, Daniel</dc:contributor> <dc:creator>Bollenbach, Tobias</dc:creator> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

Weber_263418.pdf 32

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto