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Bioavailability and potential carcinogenicity of polycyclic aromatic hydrocarbons from wood combustion particulate matter in vitro

Bioavailability and potential carcinogenicity of polycyclic aromatic hydrocarbons from wood combustion particulate matter in vitro

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GAUGGEL-LEWANDOWSKI, Susanne, Alexandra H. HEUSSNER, Pablo STEINBERG, Bart PIETERSE, Bart VAN DER BURG, Daniel DIETRICH, 2013. Bioavailability and potential carcinogenicity of polycyclic aromatic hydrocarbons from wood combustion particulate matter in vitro. In: Chemico-Biological Interactions. 206(2), pp. 411-422. ISSN 0009-2797. eISSN 1872-7786. Available under: doi: 10.1016/j.cbi.2013.05.015

@article{GauggelLewandowski2013-11-25Bioav-26329, title={Bioavailability and potential carcinogenicity of polycyclic aromatic hydrocarbons from wood combustion particulate matter in vitro}, year={2013}, doi={10.1016/j.cbi.2013.05.015}, number={2}, volume={206}, issn={0009-2797}, journal={Chemico-Biological Interactions}, pages={411--422}, author={Gauggel-Lewandowski, Susanne and Heussner, Alexandra H. and Steinberg, Pablo and Pieterse, Bart and van der Burg, Bart and Dietrich, Daniel} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/26329"> <dc:creator>van der Burg, Bart</dc:creator> <dc:contributor>Pieterse, Bart</dc:contributor> <dc:creator>Heussner, Alexandra H.</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-02-11T14:38:55Z</dcterms:available> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-02-11T14:38:55Z</dc:date> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:issued>2013-11-25</dcterms:issued> <dcterms:title>Bioavailability and potential carcinogenicity of polycyclic aromatic hydrocarbons from wood combustion particulate matter in vitro</dcterms:title> <dc:contributor>Steinberg, Pablo</dc:contributor> <dc:rights>deposit-license</dc:rights> <dc:creator>Steinberg, Pablo</dc:creator> <dc:contributor>Dietrich, Daniel</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Heussner, Alexandra H.</dc:contributor> <dc:creator>Gauggel-Lewandowski, Susanne</dc:creator> <dc:contributor>Gauggel-Lewandowski, Susanne</dc:contributor> <dc:creator>Pieterse, Bart</dc:creator> <dcterms:abstract xml:lang="eng">Due to increasing energy demand and limited fossil fuels, renewable energy sources have gained in importance. Particulate matter (PM) in general, but also PM from the combustion of wood is known to exert adverse health effects in human. These are often related to specific toxic compounds adsorbed to the PM surface, such as polycyclic aromatic hydrocarbons (PAH), of which some are known human carcinogens. This study focused on the bioavailability of PAHs and on the tumor initiation potential of wood combustion PM, using the PAH CALUX® reporter gene assay and the BALB/c 3T3 cell transformation assay, respectively. For this, both cell assays were exposed to PM and their respective organic extracts from varying degrees of combustion. The PAH CALUX® experiments demonstrated a concentration–response relationship matching the PAHs detected in the samples. Contrary to expectations, PM samples from complete (CC) and incomplete combustion (IC) provided for a stronger and weaker response, respectively, suggesting that PAH were more readily bioavailable in PM from CC. These findings were corroborated via PAH spiking experiments indicating that IC PM contains organic components that strongly adsorb PAH thereby reducing their bioavailability. The results obtained with organic extracts in the cell transformation assay presented the highest potential for carcinogenicity in samples with high PAH contents, albeit PM from CC also demonstrated a carcinogenic potential. In conclusion, the in vitro assays employed emphasize that CC produces PM with low PAH content however with a general higher bioavailability and thus with a nearly similar carcinogenic potential than IC PM.</dcterms:abstract> <dc:language>eng</dc:language> <dc:contributor>van der Burg, Bart</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/26329"/> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/26329/2/Gauggel-Lewandowski_263290.pdf"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/26329/2/Gauggel-Lewandowski_263290.pdf"/> <dc:creator>Dietrich, Daniel</dc:creator> <dcterms:bibliographicCitation>Chemico-Biological Interactions ; 206 (2013), 2. - S. 411-422</dcterms:bibliographicCitation> </rdf:Description> </rdf:RDF>

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