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C-(alpha-D-Glucopyranosyl)-phenyldiazomethanes - Irreversible Inhibitors of alpha-Glucosidase

C-(alpha-D-Glucopyranosyl)-phenyldiazomethanes - Irreversible Inhibitors of alpha-Glucosidase


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Prüfsumme: MD5:8eb6a104078f51027b52ebfa85315c5a

GENG, Yiqun, Amit KUMAR, Hassan M. FAIDALLAH, Hassan A. ALBAR, Ibrahim A. MHKALID, Richard R. SCHMIDT, 2013. C-(alpha-D-Glucopyranosyl)-phenyldiazomethanes - Irreversible Inhibitors of alpha-Glucosidase. In: Bioorganic & Medicinal Chemistry. 21(16), pp. 4793-4802. ISSN 0968-0896. eISSN 1464-3391. Available under: doi: 10.1016/j.bmc.2013.05.055

@article{Geng2013-08-15Calph-26061, title={C-(alpha-D-Glucopyranosyl)-phenyldiazomethanes - Irreversible Inhibitors of alpha-Glucosidase}, year={2013}, doi={10.1016/j.bmc.2013.05.055}, number={16}, volume={21}, issn={0968-0896}, journal={Bioorganic & Medicinal Chemistry}, pages={4793--4802}, author={Geng, Yiqun and Kumar, Amit and Faidallah, Hassan M. and Albar, Hassan A. and Mhkalid, Ibrahim A. and Schmidt, Richard R.} }

Several C-(alpha-D-glucopyranosyl)-phenyldiazomethanes, with different substituent groups at the paraposition of the phenyl ring, were prepared. The stabilities of these diazo compounds were investigated through NMR and UV monitoring. The para-cyano substituted diazo compound was found to be stable in neutral media (pH 7.0 buffer) and could be isolated. Inhibitory activity investigations indicated that this compound is an irreversible inhibitor against a-glucosidase from Saccharomyces cerevisiae. Schmidt, Richard R. Mhkalid, Ibrahim A. Faidallah, Hassan M. Schmidt, Richard R. Geng, Yiqun eng Faidallah, Hassan M. Kumar, Amit Albar, Hassan A. Albar, Hassan A. Mhkalid, Ibrahim A. Geng, Yiqun C-(alpha-D-Glucopyranosyl)-phenyldiazomethanes - Irreversible Inhibitors of alpha-Glucosidase 2013-08-15 Kumar, Amit Bioorganic & Medicinal Chemistry ; 21 (2013), 16. - S. 4793-4802 2014-02-14T12:45:50Z 2014-09-29T22:25:06Z terms-of-use

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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